Listen In - Bitesize Bio Webinar Audios
The Listen In podcast from Bitesize Bio is a compilation of our best webinars to enjoy at your leisure, wherever and whenever. Each episode is an opportunity to gain the valuable insights you need to advance your research. From a crash course in developing fool-proof ELISAs to the latest applications and innovations in CRISPR/Cas9 and microscopy techniques, and much more—you'll hear about challenges encountered and discover practical solutions to achieve the best possible results. Tap into the experience and expertise of leading researchers and commercial specialists to drive your research projects forward efficiently and productively. Listen In now! https://bitesizebio.com/listen-in/
Episodes
Discover integrated solutions for precise serial sectioning and cryo-EM sample prep—supporting seamless workflows from ultramicrotomy to 3D electron microscopy.
In this podcast, you will learn:
• How to streamline serial sectioning for volume EM using the UC Enuity and AT module;
• How to achieve in-situ targeting under cryogenic conditions for cryo-EM workflows;
• How integrated imaging and AI-powered analysis enhanc...
Learn how to perform a powerful new tissue-clearing method, designed for whole-brain 3D spatial RNA imaging at single cell resolution, and able to provide uniform staining while enhancing tissue transparency in whole organs across multiple species.
In this webinar, you will learn:
• A groundbreaking tissue-clearing technique for precise whole-brain 3D spatial RNA imaging at single-cell resolution;
• How to use it for ...
Detecting rare antigen-specific T-cell responses requires assays that are both sensitive and scalable. Traditional methods like flow cytometry often struggle with high-throughput needs or with preserving precious sample material.
In this episode of Listen In, you’ll discover how ELISpot and FluoroSpot assays overcome these challenges. These cell-based immunoassays measure cytokine and antibody secretion at the single-cell l...
In the life sciences, an astounding amount of unused products and materials end up in landfills instead of contributing to research progress. This issue arises across the product lifecycle, from liquidated biotech start-ups that abandon equipment to over-purchasing and pipeline deprioritization at successful firms. Even well-intentioned suppliers encounter forecasting challenges that leave perfectly good items discarded!
In...
Automated counting of certain cell types is notoriously challenging due to their irregular shapes, variable nuclei number, autofluorescence, and often high amounts of debris in samples.
However, with the latest developments in cell-counting hardware and app technology, automated counting of even challenging cells is simpler than ever.
In this episode, see how you can achieve reliable automated cell counts with the CellDrop A...
In this episode of Listen In, we showcase cutting-edge mass spectrometric analysis of mucins, including the characterization of mucinases, enrichment techniques, and complete mucinomic mapping of translationally relevant mucin proteins.
Mucins are a diverse family of high molecular weight glycoproteins that play critical roles in protecting and lubricating epithelial surfaces, making them integral to numerous physiological ...
In this episode, learn about latest advancements in multiplex assay technology.
Hear from real user experience how the advanced xMAP INTELLIFLEX® DR-SE Instrument revolutionizes assay multiplexing, enabling simultaneous rapid data acquisition for multiple sample parameters to expand the depth and breadth of your research.
Watch the full presentation here: https://events.bitesizebio.com/user-experience-of-the-xmap
This compact...
Immunoassays are pivotal in scientific research, enabling the precise identification and measurement of specific analytes. They pave the way for investigations into disease mechanisms, discovering biomarkers, and evaluating the efficacy of potential therapeutic interventions.
The key reagents included in an immunoassay can significantly impact reliability and reproducibility, underscoring the importance of understanding cri...
Multicolor 3D fluorescent confocal microscopy presents significant challenges in image acquisition and data analysis. However, AI is making a massive impact on 3D spatial biology.
This episode of Listen In explores the incorporation of AIVIA, an AI-powered image analysis software, into workflows to address these challenges in analyzing multicolor fluorescent microscopy data of 3D organoids.
See how AIVIA’s tools enhance th...
In this episode of Listen In, explore high-throughput and wide-range protein concentration analysis that can deliver a 20-fold improvement in time and budget savings.
Protein concentration is an obligatory critical quality attribute necessary to determine total protein content in biopharmaceutical formulations.
Concentration determination is necessary before many downstream assays. A UV-based spectrophotometric assay using ...
Learn more about the capabilities of MULTI-seq in single-cell sequencing in this episode of Listen In. Developed by the Gartner Lab at UCSF, this innovative multiplexing method increases sample and cell throughput while minimizing cost and improving your data quality.
From modest experiments to expansive 96-plex studies and beyond, MULTI-seq enables truly mechanistic studies. Hit play to explore the potential of this tool ...
A major question in developmental biology is understanding how cellular fate decisions are regulated precisely in space and time.
Fortunately, we can now begin to observe these processes with modern imaging approaches, which allow the tracking of cell fate decision events and cellular rearrangements by live 3D time-lapse microscopy.
This development is shifting our understanding of pattern formation in development away fro...
In this episode, learn how AI-powered segmentation, spatial analysis, and phenotyping can help you gain new insights for 3D images with complex morphological measurements featuring up to 15 biomarkers.
See how to characterize tissue microenvironments and examine the differences between normal and disease tissues without the need to code or train Deep Learning models—all with Aivia.
Plus, get your 3D spatial biology res...
Imaging scientists have a critical educational role in improving rigor and reproducibility by sharing their technical expertise and providing intellectual contributions in all aspects of image-based science.
They participate in creating, developing, and disseminating guidelines, resources, and tools to improve image-based research.
In this episode, learn what impacts reproducibility in microscopy, discover resources and ini...
Immunoassays play an indispensable role in scientific research. They facilitate the detection and quantification of specific analytes, enabling in-depth investigations into disease mechanisms, biomarker discovery, and evaluation of the potential of therapeutic interventions.
Sample selection and preparation are of utmost importance, as they have a direct impact on the accuracy, reliability, and integrity of the obtained res...
The brain is an immune-privileged organ, meaning it is protected from the entry of pathogens, blood circulating factors, and immune cells by a physical barrier called the blood-brain barrier (BBB).
But pathological events such as ischemia (stroke), trauma (traumatic brain injury), or tumor growth (gliomas and brain metastasis), activate the vascular endothelium, disturb or disrupt the BBB and allow immune cell homing.
In th...
Tissue heterogeneity is a significant challenge when analyzing proteins in tissue samples to identify disease states.
In this episode, explore how combining laser microdissection with mass spectrometry (LCM-MS) on fixed and stained tissues lets you explore the protein networks within pathological features to shed light on their molecular functions.
Using hallmark lesions of lung fibrosis in the honeycomb airways and fibrobl...
Join Advanced Workflow Specialists for a virtual reality showcase of Leica's confocal microscopy platform, STELLARIS.
In this episode of Listen In, discover how to enhance your confocal imaging from performing multicolor experiments with clear, sharp images to capturing fluorescence intensity and lifetime-based information simultaneously.
Watch the full presentation here: https://microscopyfocus.com/confocal-microscopy-stel...
The fundamental cellular mechanisms of internalization and trafficking are crucial to many areas of cell biology, especially the proper function of therapeutic antibodies.
Antibodies intended for use as antibody-drug conjugates (ADCs) should specifically bind to target cells and rapidly internalize via endocytosis.
However, the ability to study these processes has historically been limited by the lack of tools that dir...
Join us on Listen In as we unveil a breakthrough method for imaging skin immune cells, crucial for accurate diagnoses and personalized treatments.
Traditional imaging faces challenges like high tissue autofluorescence and spectral spillover. However, our latest episode introduces a game-changing solution using the Leica SP8 microscope coupled with the MANTIS system.
Learn how this innovative approach allows for the acquisit...
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