The CIRS Group Podcast

Barbara and Jacie continue their CIRSx 2026 recap with the medical talks, emphasizing that the episode should not be considered medical advice and encouraging listeners to consult their own CIRS practitioners. They summarize Dr. Ritchie Shoemaker’s talk on “triple positives” on GENIE (AKT, RELA, tubulin) as an early risk pattern for neurodegeneration including Parkinson’s, highlighting the promise of early i...

Barbara and Jacie kick off their annual CIRSx 2026 Conference recap series, focusing this episode on remediation and environmental talks, with a reminder to consult an indoor environmental professional (IEP) for climate-specific guidance. They summarize key presentations: Bill Weber and Christine Semabeu on prevention-first building and homeowner maintenance (leak management, access panels, alarms, early mechanical planning, and th...

Barbara and Jacie share “hot takes” after CIRSx 2026 in Fort Lauderdale. Barbara attended in person and Jacie watched virtually. They discuss feeling “weird vibes” and a more corporate yet conflicted identity, with misalignment about whether the conference is for providers, patients, or remediators, and concerns about limited innovation within the Shoemaker community. They encourage practitioners to seek inn...

In this The CIRS Group Podcast episode, Jacie and Barbara explain MARCoNS (multiple antibiotic resistant coagulase-negative staphylococci) as a common deep nasal colonization in CIRS patients and why it’s addressed as step three in the Shoemaker Protocol (after leaving exposure and using binders). They discuss how MARCoNS may perpetuate inflammation and low MSH, what symptoms can look like, and how to test via a deep nasal sw...

On this episode of The CIRS Group podcast, hosts Jacie and Barbara interview Dr. Andrew Heyman about Dr. Naviaux’s cell danger response (CDR) framework and why it can explain stalled recoveries in chronic mold-related illness and CIRS. Heyman describes how mitochondrial “danger mode” drives three phases: initial inflammation (innate immune activation), rebuilding via aerobic glycolysis, and reintegration requiring...

Barbara and Jacie wrap up their five-part Shoemaker Protocol series with Phase 5: Repair and Restore. This phase focuses on normalizing innate immune markers (MMP-9, C3a, C4a, and TGFb1) and restoring brain volume. They explain that low-starch/gluten-free diet helps bring down MMP-9, while persistently elevated C3a/C4a or TGFb1 often signal ongoing exposure, gut issues, tick-borne illness, or dental cavitations. The episode culmina...

In this CIRS Group Podcast episode, Jacie and Barbara cover phase four of the Shoemaker Protocol, focused on restoring normal metabolic function after biotoxin elimination. They explain that this phase may include supporting detox pathways for “normal” toxins and heavy metals (e.g., daily bowel movements, B vitamins, methylation support, sauna or hot baths, lymphatic techniques, and using binders like charcoal or clay f...

Struggling with stubborn biotoxin illness (CIRS) and feeling stuck in your recovery? In this episode, we break down some of the most important (and often overlooked) steps in the Shoemaker Protocol, including binders, MARCoNS treatment, and gut support. Learn how binders like cholestyramine and Welchol work differently to remove biotoxins, why the wrong detox approach can trigger setbacks, and how to track your progress with tools ...

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Is mold colonization the same as CIRS? Could what looks like a fungal infection actually be something else entirely? In this episode, Barbara is joined by Dr. Lacey Venanzi and Dr. Christian Navarro-Torres to break down the difference between mold/fungal colonization and chronic inflammatory response syndrome (CIRS), explore the surprisingly important role of act...

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Jacie and Barbara cover Phase Two (part two of five) of the Shoemaker Protocol for CIRS, focusing on foundational steps before starting binders: 

Lipid replacement therapy (primarily fish oil) to lower inflammation and help prevent common binder side effects like fatigue, constipation, and overall dryness, with Shoemaker-recommended omega-3 dosing (EPA 2,400...

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Uncover the truth behind chronic illnesses that are often misdiagnosed for years. If you’ve been told your symptoms are anxiety, IBS, or autoimmune, this episode explores a groundbreaking approach that could change everything. Learn how the Shoemaker Protocol, backed by clinical research, helps identify and treat CIRS (Chronic Inflammatory Response Syndrome...

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Jacie and Barbara discuss chronic fatigue syndrome (ME/CFS), emphasizing it as a real, multisystem illness rather than “just being tired,” and describe hallmark symptoms like post-exertional malaise (PEM), unrefreshing sleep, brain fog/word-finding issues, orthostatic intolerance, sensory sensitivity, pain, headaches, and the push-crash cycle. They ex...

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In this episode, Barbara and Jacie discuss how CIRS patients can tell when they’re ready to move to the next step of the Shoemaker Protocol or “graduate,." As always, healing is gradual and should be guided by a CIRS-literate practitioner. They recommend tracking symptoms over time and checking three key questions: whether symptoms are improving, whet...

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In their 150th The CIRS Group podcast episode(!!), Jacie and Barbara share practical guidance for reducing actinos in the home, emphasizing that consistent removal matters because a CIRS patient can react whether actinos are dead or alive. This is NOT medical advice: Actinos guidance is leading-edge in the CIRS space, but they share what has worked for them and m...

To check out the actinos cleaning protocol class Barbara just recorded, join us at https://thecirsgroup.com

Barbara and Jacie discuss actinos (actinobacteria) in the context of CIRS and how they can drive illness. Notably, Genie Test research suggests 42% of CIRS patients react to Actinos versus 30% to endotoxins and about 10% to mycotoxins. Today's episode covers testing strategies, and if human-derived actino scores are high, the...

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Jacie and Barbara return from an unexpected break, caused by Jacie's autoimmune flare after moving into an apartment with a high actino score. Today's episode outlines what to do during a CIRS “flare” or symptom backslide. Some tips covered inclide: defining early warning signs, using objective tracking tools like the VCS test, symptom logs, and weara...

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Jacie and Barbara discuss why unlimited money and access to extreme treatments doesn’t usually lead to better or faster healing. Wealth can remove “financial friction,” which inadvertently encourages fear-based, urgent, and uncoordinated decision-making, including fringe or unregulated therapies, constant protocol switching, and symptom-focused ...

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In this week's episode, Barbara and Jacie explain why people with Chronic Inflammatory Response Syndrome (CIRS) or mold illness should test their home (and workplaces) and when. They'll dig into why multiple tests are better to understand the full picture rather than relying on a single score, and recommend working with an IEP (Indoor Environmental Professional) ...

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Jacie and Barbara discuss how CIRS commonly affects body weight: often causing weight gain and resistance to fat loss, though some people experience extreme weight loss. They'll dig into why weight changes are driven by chronic, multi-system inflammation from biotoxin exposure (such as mold or Lyme), impacting hormones, metabolism, detox pathways, the brain, and ...