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July 25, 2023 • 46 mins

This week, Rosie chats with bariatric surgeon, Dr. Daniel Rosen. Rosie was recently prescribed Mounjaro to control her diabetes. (Mounjaro is approved strictly to treat Type 2 diabetes and it has not yet been F.D.A approved as a weight loss drug.) Since being on it, Rosie has experienced slow and steady weight loss and, even more surprising, she's been able to say goodbye to the non-stop food chatter she's had to deal with for years. In her opinion, Rosie's been given a miracle drug and she wanted more info about it to be able to share whatever trusted information she could find with others. Dr. Rosen, as a medical specialist in both weight management and specifically Mounjaro, is on TikTok relaying reliable and relatable information to help answer questions and to remove stigma surrounding obesity and its treatments. So Rosie reached out to him. Listen in as they discuss these new drugs, costs, the diet industry, and living a healthy positive shame-free lifestyle.

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Episode Transcript

Available transcripts are automatically generated. Complete accuracy is not guaranteed.
Speaker 1 (00:11):
Well, hey everybody, it's me Rosie O'Donnell and how are
you on this fine day? It must be Tuesday, because
we're dropping a new one. Yes, this is onward with me,
your host. So here's what we wanted to try a
little something different today. I want to talk about my
weight and issues with my weight. And I didn't know
really exactly how to do it, because you know, there's

(00:34):
so many things to address within it, and so many
causes of what makes someone obese. And I am on Munjaro,
which is a diabetes medicine, and I've been on it
since December and I've lost nearly thirty pounds on it.
I'm on the lowest dose. And I was going through

(00:56):
my TikTok one day and I see this guy, doctor Daniels,
and he's adorable and he's from New York and he
used to work at Beth Israel, where I had a
little boutique named after my mother with wigs and hair
care and hats and things for women going through chemo,
called the Roseanne o'donald Boutique. And the hospital is no more,

(01:20):
but still I really always have wonderful feelings about that place.
And so I started talking to him, because I heard
him one day say, thank God that Rosie O'Donnell admitted
that she's on Manjaro. And you know, listen, it wasn't
so hard for me to admit. I found out I
had diabetes, and they gave me this medicine, and before

(01:42):
I knew it, I had lost twelve pounds and then
I kept losing, you know, but it's slow and steady
for me. And I had the vertical gastric sleeve about
twelve years ago, and so my stomach is much smaller
than the average person on these meds. So we're on
the lowest dose and my doctor has decided along with

(02:03):
me that that works best for me. And even though
I'm losing weight slowly, I continue to lose and I
continue to feel satiated and healthier. You know, I feel
like food controlling my life and world is over, at
least on this medication. It sure feels like it's over.

(02:24):
I mean, it's as if every single thought of food
has been deleted from your memory block, you know it
used to be. I would be in my bed thinking,
I think we bought those many drumsticks for Dakota. I
bet I could go downstairs and get one. Well they're minis.

(02:45):
Maybe I'll have two. Like I had to negotiate with
the calling of every sugary product in my house. But
since December, I've been on this Munjarro and well it's
been life change and I want to talk about it.
And I thought i'd just have this chat with doctor
Daniel Rosen and we'll see. You know, there's so many

(03:07):
issues around obesity. There's so many emotional parts of weight gain,
and yet with this drug, it makes you feel as though, no,
it's all biological. You know, all of us thinking it
was a lack of willpower or listen, Once you get

(03:28):
the shot, you like, free yourself from all the guilt
that you carried for so long living in a society
that marginalizes, embarrass is, and shames over weight people. You know,
weight is an issue for everyone, some presidents, some rock stars,
some talk show hosts, and teachers and mailmen and everyone

(03:50):
in the world. It's a problem in America, and it's
something I fought with a long time. So we've got
him here, doctor Daniel Rosen, and we're not going to
take any questions. We're just going to chat and see
what happens. But enjoy doctor Daniel Rosen, and I han't
a chat about weight and whatnot. Well, Hello Daniel Rosen.

Speaker 2 (04:22):
Hi Rosie, how are you?

Speaker 1 (04:23):
Oh well, how are you?

Speaker 2 (04:25):
I'm great? I'm great. Busy day with patients.

Speaker 1 (04:28):
Oh yeah, now you are an MD? Should I call
you doctor Daniel Rosen?

Speaker 3 (04:32):
You can call me doctor Daniel Rosen, or you can
call me doctor Rosen, or you can call me Daniel.

Speaker 2 (04:37):
All right, it's all good. I'm not that formal, right.

Speaker 1 (04:40):
I saw you on Instagram and I was like, this guy.
I enjoy what he's saying about weight and about the
cultural stigmas associated and these new medications that Di'm on
and so many people are on. And I thought a
lot of people are interested in my journey with weight,

(05:01):
and I thought, maybe you and I can go through
it together and not necessarily answer questions that I have,
but talk about the things that I've done, as I've
battled obesity pretty much for much of my adult life.

Speaker 2 (05:15):
Yeah. I would love to do that.

Speaker 1 (05:17):
So where do you think we begin? Where do you
want to start in terms of my weight stuff?

Speaker 3 (05:23):
I mean, what I would really like to hear is
a little bit of background about how your weight impacted
you in your younger years, because so much of what
people carry about themselves, their worth, their body, their desirability

(05:44):
in society comes from their early years with their family,
especially if you have parents who aren't obese and you
are obese, or you're part of an obese family that
experiences shame from the outside and also in relationships as
you sort of become an adult.

Speaker 1 (06:05):
Well, you know, it's interesting. I don't remember having anything
to do with Wade until after my mother died, so
that was nineteen seventy three. So I was not like
a fat kid. Nobody called me names, nobody teased me.
And then when I got to be you know, ten,
I was doing athletics a lot, so I did every sport.

(06:27):
You know, I was a tomboy, and it wasn't I
wasn't like the fat girl in school. You know. I
was in the musicals, I was in student council. I
was the prom queen, I was the homecoming queen. I
was missed high school. I succeeded so much at high school.

Speaker 2 (06:44):
So you peaked in high school, Rosie.

Speaker 1 (06:45):
I kind of did you know. I was looking for
the adults' attention and the teachers. You know, I would
try to make the teachers laugh more so than my
classmates laugh at the teacher. So I had wonderful relationships
with some of the teachers that really changed my life,
where they took me in and loved me. And it

(07:06):
wasn't until I got to college that I started gaining weight.
So that was about, you know, eighteen, nineteen twenty, I guess.

Speaker 3 (07:16):
Yeah, that's usually the first period of weight gain, especially
for women. Obviously they talk about like the freshman fifteen
in and of itself has a bit of a negative
connotation because everything with weight has a negative connotation.

Speaker 1 (07:30):
Yeah, well, you know, I kind of rode the edge
of being able to fit in the gap and having
to go to Lane Bryant like I never really you know,
went past like in eighteen, I you know what you
can get at the gap if you're lucky and you
go when they first put them out on the shelves.
But the next time I remember my weight being a

(07:51):
problem was in League of their Own. Penny said, I
want you to lose twenty pounds, and I said, Penn,
if I could lose twenty pounds, I would, right. Nobody
who's heavy keeps it on for fun, right, So you
know when one of these other women can hit the
ball out of the park like I can, then I'll
lose twenty pounds. But until then, this is how my

(08:11):
body is. And she was like, Okay, well, we all
say it would look better if you're but it didn't
infringe on anything. I still was, you know, able to
be in the movie. And you know, it wasn't until
my show that I really remember gaining weight. From the

(08:33):
June that it started until that first Christmas break, I
think I gained a lot of weight and uh, the stress. Yeah,
superstardom is close to post mortem, Eminem says, but it's
you know, it's a very strange thing to go from
a normal life, even within show business to what happened
to me with that show at a time when there

(08:54):
was no internet, so a vast majority of people were
watching you. It was a different thing than TV is
now and what daytime TV is. It was the heyday
of daytime TV.

Speaker 3 (09:06):
I remember even before that, Rosie, if I can sort
of go back to, you know, my twenties, I feel
like you were exposed to a lot of scrutiny. Yeah
in exit to Eden, Yeah remember, yeah, like you looked phenomenal. Yeah,
I mean, you must be so happy some of those

(09:28):
pictures were taken.

Speaker 1 (09:29):
Well, you know, it's funny because I took the role
because they offered it to Sharon Stone and she said no,
and then they offered it to me, and I thought,
when in my life is that going to happen? That
the character could either be Sharon Stone or Rosie O'Donnell.
So I took it knowing that it was going to

(09:50):
push me in ways I had never been pushed, you know.
Wearing that outfit was the first time I had ever
worn something even close to obayathing suit. I would wear
a sports bra, Nike long bite shorts and a T
shirt in the pool, right. And it wasn't until I
had children that I realized what I was doing and

(10:12):
saying to them about my body shame that I stopped
doing that and bought a bathing suit. And you know,
it's taken a while. I mean, I know that for me,
those pictures kind of doesn't feel like me, you know,
but but it's the first day I went to the set,

(10:33):
I had my robe on and I was really nervous
and I didn't want anyone to like look at me,
And so then I took the robe off, and you know,
one of the GRIP guys goes, hey, looking good, O
D now? And I was like what. And then the
next day like that, like you know, Gary must have said,
go tell she's looked nervous, go over there. And so
the Marshall family's given me my whole career. But they

(10:53):
came and told me how great I looked. And then
like by the third day, I was able to be
on the set in it and not feel horribly, you know,
embarrassed or ashamed, and you know what's intermingled with that
and with your body and trying to kind of not
be sexual. You know, some people I think who maybe

(11:16):
had sexual traumas children maybe don't want their body to
be appealing to someone unless they want the someone so
they can decide.

Speaker 2 (11:26):
Yeah.

Speaker 3 (11:26):
I mean, people see themselves in their body in ways
that are sometimes not at all you know, a reality
to those around them. I see patients and I wonder
if you experienced that, yes, in your weight loss journey,
that aha moment when you look in the mirror and

(11:47):
you don't recognize that person.

Speaker 1 (11:49):
Well, you know, it's interesting. I really have to look
at myself in photos in order to see myself accurately.
The mirror doesn't do it for me, Like I don't
look in the mirror and see any difference. Hey, don't
go away, there's more to come. You know. I've been

(12:26):
on which we're going to talk about, Manjaro for six months,
since December sixteenth, and I've lost about twenty seven twenty
eight pounds and now I'm down to losing maybe half
a pound or a pound a month. But I'm still
on two point five because, as you know, I had
the vertical gas sleeve and my doctor feels if it's

(12:50):
curtailing my appetite and helping with my satiation, why go up?
You know, there's no reason I'm not like dying to be,
you know, a size eight. I'm happy with the progress,
and I think it gives me enough time to catch
up to not be scared. You know.

Speaker 3 (13:09):
Yeah, I think that's really important. And I deal with
patients in terms of prescribing Manjaro for people who have
bariatric surgery and also for people who want to avoid
bariatric surgery or are scared of bariatric surgery.

Speaker 2 (13:23):
And you see everything.

Speaker 3 (13:25):
You see the people who really want to ride the
lowest possible dose as long as they can and are
focused immediately from the beginning on when can I get
off this?

Speaker 2 (13:35):
Or how do I get off this?

Speaker 3 (13:37):
And then you have people who want headle to the
floor maximal weight loss every month, you know, momentum to
try and get a large amount of weight off. Yeah,
and it's different philosophies. And what's great about going slow
and steady is you have all of this upside in

(13:58):
front of you.

Speaker 2 (14:00):
Should it be necessary?

Speaker 1 (14:01):
Right?

Speaker 2 (14:02):
And you're not burning your options early because you're kind
of greedy.

Speaker 1 (14:06):
You know when you say some people who stay on
the low dose and think when can I get off this?
I stay on the low dose and hope I never
get off it. I really do. I feel in many
ways it's a miracle drug. And I really wish that
Eli Lilly would understand what it is to people and
how it is life altering and how there would be

(14:28):
saving so many people's lives, not only for the physical health,
but for the mental shame that you carry around as
being called fat and a pig and a cow and
ugly and you know, called it not only by mean
bullies on Twitter, but called it by you know, the president,
talk show hosts.

Speaker 3 (14:48):
You know, like there family members fit exactly, well meaning siblings.

Speaker 1 (14:54):
Yeah, yeah, And I think it's a life saving drug.
I would love to say to Eli Lily, I'll be
your spokesperson. If you can cut the price to ten
percent of what it is, I'll do it for nothing.

Speaker 3 (15:06):
Right.

Speaker 2 (15:07):
But don't you think they know what they have?

Speaker 1 (15:09):
I believe it's changed my whole world and my whole life.
I think they know what they have, and they know
what they make on all their other drugs. And do
they have to gouge this clientele that has been lied
to by the medical community. But here is a drug
that somehow tricks your brain into thinking that you don't

(15:30):
want the brownie. And guess what it feels like, freedom
to not want the brownie?

Speaker 4 (15:36):
Right?

Speaker 3 (15:37):
The food chatter, the cravings that drive you when those
are quieted, all of a sudden.

Speaker 1 (15:43):
Not quiet, it gone, They're gone, Gone're gone.

Speaker 3 (15:47):
Right.

Speaker 1 (15:48):
That's why I think this medicine has to be applicable
to addiction on the whole.

Speaker 2 (15:53):
Well, here we'll see.

Speaker 1 (15:54):
Because as much as you thought it was willpower or
a character defect for someone to be that, you give
them this medicine and their body starts acting as if
it's not and before you know it, it's.

Speaker 3 (16:08):
Not Yeah, a lot of these studies are going to
be coming out in the next few years. These drugs
are impacting people with addiction. I can speak to a
patient who came to see me, and she was a woman.
She actually had a sleeve gastroctomy as well, and she
had lost about one hundred and twenty pounds and she

(16:29):
had regained fifty pounds and was really distraught about it.
And she told me that, you know, in asking about
her medical history and whether she drinks alcohol, she said, yeah,
she's like a frat boy. She has six beers a
night and twelve a day on the weekend. And I
of course told her that that's way too much alcohol
for her liver, which is probably filled with fat, you know,

(16:51):
as a lot of obese people have fatty liver.

Speaker 2 (16:53):
But that also it's a lot of calories.

Speaker 3 (16:56):
It's about six hundred and fifty to twelve hundred calories
a day that she doesn't need to have. And I
really encourage her to try and get off of drinking.
And I mentioned that people who have taken this medication
have said they've lost their craving for alcohol, and she
has had one beer in four months and has lost

(17:19):
thirty five pounds.

Speaker 1 (17:20):
Well that's kind of miraculous. I mean, have you heard
about the people who switch addictions that they have the
vertical sleeve and then they become alcoholics.

Speaker 3 (17:30):
Yeah, absolutely, addiction transfer, that's a real thing. It's absolutely
a real thing. Addiction transfer. You know, when you have
a sleeve, you can't get that numb doubt feeling from
binging on food because your stomach is so restricted, and
you know, your brain will look to adapt and find

(17:51):
that dopamine, that stress release that you have become so
accustomed to receiving by overeating with other dopamine releasing activities
like gambling, like sex, like alcohol, or drugs. So absolutely,
addiction transfer is a real thing. Their numbers are between
five and ten percent of people have baratric surgery end up,

(18:12):
you know, switching to a different addiction.

Speaker 1 (18:16):
Yeah, that's that's a horrible thing.

Speaker 2 (18:18):
Gary.

Speaker 1 (18:19):
Imagine you try to fix one thing and you get
hit with another, a double whammy.

Speaker 2 (18:24):
The brain has its ways.

Speaker 1 (18:26):
Yeah, Well, why do you think this medication is able
to quell the food chatter?

Speaker 3 (18:33):
Well, it's super interesting. The way these medications were developed
was by reverse engineering bariatric surgeries, So really the main
one was a gastric bypass. You had a gastric sleeve,
and when you take out a large portion of the stomach,
it lowers a hormone called grellin, which is a big

(18:54):
driver of hunger. So you know, you think of hunger
and fullness on a seesaw, or we would say hunger
in satiety on a seesaw. And so the sleeve works
in one way by dropping your grellin, because when you
take out a portion of the stomach, especially the part
that makes the grellin, your grellin levels circulating go down,
and your brain is picking up a big drop in grellin,

(19:17):
so your brain experiences grellin as be hungry. So when
the grellin levels down, your hunger is gone. And people
say when they have a sleeve gas stricting me, it's
like I surgically removed their appetite. And the other thing
it does is your stomach isn't this bag that can
mechanically break down food as effectively. So food ends up

(19:37):
sort of more chunky and less broken down, less surface
area exposed to the intestinal enzymes, and therefore the food
travels farther down into the intestine, and when the food
reaches the end of the intestine, your body has all
of these mechanisms to prevent losing those calories. And so

(19:59):
the very end end of the line on your intestines
has these sensor cells that when they see nutrients, specifically
fats and proteins, they send these strong hormones, one of
which is GLP one that tells your brain stop eating.
And your brain experiences that as you're not hungry, even

(20:19):
the pushing away from the table in Thanksgiving where you
can't you're like, I can't eat another bite, or I
feel the food in my throat. You don't really feel
the food in their throat. There's no food in your throat,
but your brain is creating that sensation to get you
to stop eating because foods hit the end of the
line and you don't want to waste food and lose

(20:40):
those calories because who knows when your next meal is coming. Evolutionarily,
you don't know when the next mammoth you'll take down
for the whole community to get a chance to eat.
So it stops the consumption so the intestines can catch up.
And so what they found, especially with gastric bypass where
you re route the intestine so the food sort of
drops in at the fifty yard line. Is that people

(21:04):
experienced this incredible sense of fullness and their blood sugars normalized.
People were able to get off diabetes medication before they
lost any weight. So that was the aha moment that
you know obesity and diabetes that they can get better
even before you lose the weight. And so Manjaro is

(21:26):
a diabetes medication. And it was through understanding what are
the hormonal changes that happen when food hits the end
of the intestine and people's blood sugars normalize. What is
causing that? And they found out that it's GLP one,
another hormone called peptide Why Why, which by the way,
is going to be a future drug coming out in

(21:46):
this whole sort of gi peptide drug class. So it's
these GLP one medications that tells your brain you've just
had a big meal, except you haven't eaten anything. So
it's it's that hormonal release that says you're good, you're full,

(22:08):
you don't want anything, you don't need anything, even though
you haven't eaten anything. That's the big trick that these
new drugs are able to cause in your brain.

Speaker 1 (22:18):
It's pretty incredible. I have to say, you know, it
used to be when Halloween happened my kids, like would
have you know, four kids all around the same age.
They had pillowcases full of candy, and it was physically
impossible for me to stay in my room and know
that all I had to do was find their candy bag,

(22:40):
which they wisely hid, and then I could eat one
hundred thousand dollar bar or some other childhood chocolate. That
still beckons to me, you know. And the fact that
you know, I have a woman who's a chef cooking
for me in my effort to eat more healthy, and
she makes healthy cookie brownie things and I don't even

(23:03):
eat them. I walk in the kitchen, I see warm
brownies and I go, no, thank you. And I'm not
trying to I'm not, you know, part of me, missus
wanting it, you know, like I smell it and I go,
oh yeah, but I don't want to eat it.

Speaker 2 (23:19):
But now you have the power. You have the power.

Speaker 1 (23:22):
Now, I guess right. It's changed everything in terms of food.
I would do the Tonight show and I would think,
don't eat the cookies, don't eat the cookies. Most comics
are worrying what's going to be their stand up act.
I'm trying not to eat the snack food in the
green room. You know, all of that feels like a
history that I don't even recall. Now, you know, for

(23:45):
six months I've been free of it, and it feels miraculous.
It's really interesting how we carry it, why we carry it.
You know, I'm one of five siblings, and everyone has
the same body type, you know, torso big belly, thick
upper arms. You know, it's like we're Irish washerwomen bodies,

(24:06):
you know, and some Geraldine page stock, you know, which
is a good thing to have. But you know, I
look at families where obviously there's a problem and whether
that's genetic or whether that's the nature and the house,
and you know, everybody is so interested in what it is,

(24:28):
and all these companies that have made so much money
on trying to get us to do it their way
count points. And you know, the percentage of people that
lose weight and keep it off is what percent, doctor Rosen?

Speaker 2 (24:39):
Less than five percent?

Speaker 1 (24:40):
For sure, less than five percent.

Speaker 3 (24:43):
Yeah, And it's your fault, Rosie, right, it's if you
can't do it. It's your fault and you need to
go home and try harder.

Speaker 1 (24:49):
Right.

Speaker 3 (24:49):
How many doctors have told that to people struggling with
their weight.

Speaker 1 (24:52):
There was a doctor I never only saw her once,
and I went in and she said, you know, you're
close to two hundred pounds. I'm like, yeah, I know.
And she's like, well, you know, like when you go out,
before you leave your house, you should like cut up
some carrots and put it in a ziploc bag and
like some apples and stuff like that and just like
carry it with you. Wow. And I'm like, are you kidding?

(25:13):
Do you think I should have fruit and vegetables? Oh
my god, you've cured obesity in America. Thank you, thank
you for being my doctor. And that was the last
time I saw her, But you know, yeah, people do
kind of thank you. Slovenly and and unfocused and lacking discipline.

Speaker 3 (25:31):
You know, patients tell me all the time, I really
eat healthy. I really don't eat a lot, right because
they think I think that they must eat poorly. But
being in this profession and taking the time to get
to know my patients, I hear the stories where people

(25:54):
say I moved in with my boyfriend and he couldn't
believe how little I ate, right, because I'm three hundred
pounds and he's normal weight, and he.

Speaker 2 (26:04):
Just assumed that I over ate chronically.

Speaker 3 (26:08):
But I know from experience that most of my obese
patients eat better than.

Speaker 1 (26:12):
Me, right, And so what is that thing? Then? What
is that trigger?

Speaker 3 (26:17):
The thrifty gene? They call it the notion that you're
better at retaining calories than someone who's not programmed to
be obese. Your metabolism runs lower, so even if you
eat less calories, at the end of the day, you're
left with positive calories and that gets deposited as fat.

(26:38):
You know, can be something as simple as you don't
fidget a lot. Fidgeting might burn an extra hundred calories
a day. You know over the course of a year
that it can add up to two pounds. Over the
course of twenty five years, that can be fifty pounds, right, right,
So it's not things that are in people's control necessarily, right.
And if you work out, your brain makes you hungry,

(27:01):
so eat more to make up for the calories that
you burned, and body doesn't want to lose any calories, right,
It's got to prepare for the winter which is coming.
It doesn't know that there's a bodegon every corner with
chips and things like that.

Speaker 1 (27:15):
Have there been studies about how long one can stay
on this drug Manjarro, even at a low dose, because
I've heard people say, and a TikToker woman especially, that
she had lost all this money on one of these
Wago vio zempic Munjarro products and then went off and
gained double the weight back in a very short time.

(27:37):
And like the fear mongering is, you know, don't be
happy formerly obese people, don't feel good about yourself because
we may not let you take this for a long time.
It may be too expensive, and you know, like there's
I don't.

Speaker 2 (27:52):
Know, I'll cover it, cover it.

Speaker 3 (27:54):
We're going to take it away from you, and then
it's going to come back double, right, So so I
get that all the time. And a couple thoughts on that.
First of all, just because something may stop working doesn't
mean you shouldn't do it. Just you know, when you
stop taking tail and all your headache may come back,

(28:17):
doesn't mean you don't enjoy being headache free for four hours, right,
you know, And you know it is expensive right now,
and patients are burning through their FSA or their savings
in order to get this drug, and access is.

Speaker 2 (28:34):
A real problem right now.

Speaker 3 (28:36):
Yes, and if people do come off the medication, there's
going to be a rebound hunger, no question about it,
because there's a hunger suppression. And why there's a hunger
suppression is because the GLP one that's in higher levels
than is typical floods your brain and GLP one says

(28:57):
you're not hungry. So the receptors or GLP one are like,
oh my god, there's so much GLP one here.

Speaker 2 (29:04):
We're not hungry. But we also we don't need.

Speaker 3 (29:06):
To all be out here looking for GLP one because
there's plenty of it around. So your brain downregulates the
number of receptors. You know, your body isn't gonna spend
energy making a bunch of receptors when there's tons of
stuff around. So because there's high levels of GLPU, you
downregulate your receptors. And then if you come off your

(29:27):
mount Jaro or a zepik or WGOVI some sort of
GLP one agonist medication, especially if it's a rapid stop
all of a sudden, those fewer numbers of receptors are like,
oh my god, where did all the GLP one go?
There's no GLP one. We're hungry, We're hungry, We're right right,
and they're like, we need more receptors for GLP one.

Speaker 2 (29:51):
Quick start making receptors. Because there's not so much ELP one.

Speaker 3 (29:54):
We need even more receptors to find the little that's
out there. So now instead of saying like we're hungry,
we're hungry, it's like ten times as many receptors.

Speaker 1 (30:01):
Going we're hold right, we're hold right.

Speaker 3 (30:05):
And so you know, you can try and white knuckle
your way through, but weight regain it would be extremely
difficult to avoid in that setting. So for me, I
try and wean people off so that there isn't that
amplification of hunger.

Speaker 2 (30:22):
I think in the setting of people.

Speaker 1 (30:24):
With excuse me, but why would you wean people off
like because someone says they don't like the side effects?
I thankfully knock would haven't had any, But why would
someone say they want to go off of it?

Speaker 3 (30:34):
So first of all, I'm talking about in a setting
where let's say they can't afford it anymore.

Speaker 2 (30:40):
In an ideal setting, I wouldn't stop.

Speaker 1 (30:42):
It, like understood yes, like a knife.

Speaker 2 (30:44):
I would try and lower their dose gradually.

Speaker 3 (30:48):
Someone who's having a lot of side effects but doesn't
necessarily want to get off the medication, I would maybe
try and have them on a lower dose to see
if we can control those side effects while maintaining the
weight or at least avoiding regain, if that's a priority
for them. So, I just don't like the notion of
someone who's on this medication, especially the higher doses, and

(31:09):
then they are forced to stop, and then the weight
gain is quite can be quite devastating.

Speaker 1 (31:18):
So yeah, I have fears of that, I really do.
I have fears of it. How long can one stay
on it?

Speaker 2 (31:24):
I don't think we know.

Speaker 3 (31:26):
These medications have been around for quite a long time,
like twenty years or twenty years. Yeah, twenty two thousand
and five was the first medication in this class. They've
gotten better and better, and these mostly were diabetes medications
that were co opted because they provided effective weight loss.
And only now as it rebranded from ozemic into a

(31:48):
GOVI and they'll be coming out with it a mount
Jarro rebrand just for weight loss soon, you know, for
the time being, or anyone using it just for weight loss,
is using it off label, so we don't how long
you could be on Mount Jarro. But the good thing
about these medications that gives me hope is that they're
really biologic medication. They're really utilizing the body's own system

(32:14):
to control appetite and fullness, and that gives me hope
that you can be on them for a long time.

Speaker 1 (32:22):
Okay, good, because I would like to stay on it, Yeah,
I really would, you know. I try to explain it
to people who aren't on it, and you know, some
people that can't get their insurance, friends of mine, siblings,
people in my life. You know, it's it's a difficult
thing to get. And then even if you get the prescription,
they don't have it at the drug.

Speaker 2 (32:42):
Store, you know, or they don't have your dose.

Speaker 1 (32:45):
Yeah, I had to skip last week's shot because we
didn't have it, so I was very conscious to see
if I felt any different, and I didn't. But it
was only one week, right, right, And that's not really
something that can make a big difference right away. Like that.

Speaker 3 (33:00):
Did you notice the difference between the day before you
took the shot, meaning day eight would be one day
after you were due to take it, versus day thirteen
or fourteen.

Speaker 1 (33:12):
Well, I took it today on day fourteen.

Speaker 2 (33:15):
And how are you feeling last night?

Speaker 1 (33:18):
I felt no difference, really. I mean one thing that's different.
The only thing that was different in the week is
I had some microwave popcorn about half a bowl, and
I haven't had that in you know, months.

Speaker 3 (33:29):
So you've also been on it for a while, right,
So that kind of builds up, and the longer you've
been on it, probably the more you have in your system, yeah,
to tide you through.

Speaker 1 (33:41):
And the importance of exercise in this Manjaro thing is
something that we need to talk about too, because you know,
people are losing so much weight so quickly, and you
know you have to sort of tone the muscles and
keep yourself fit. Your core muscles, your leg muscles, you know,
super important, and especially as we get older, you know.

Speaker 3 (34:00):
The body doesn't know to protect the muscle and preferentially
take the fat if you're not giving it signals that
that muscle is necessary.

Speaker 1 (34:12):
Interesting, I saw a TikTok, which you know, you get
all the facts from TikTok, where it was an older
man who was a doctor MD, and he was saying
that even if you have an autoimmune disease and you're
you drink every night. You know, the guy who exercises
is going to live longer than you. You know, like
he was saying, no matter what you do, you have

(34:33):
to exercise, move it or lose it. That's you know.

Speaker 3 (34:36):
Yeah, it's important. And I tell patients if they want
to lose weight, exercise will make that weight loss happen
quicker because if you're running a calorie deficit, if you
burn more calories, it just exaggerates that deficit. But it's
also so helpful in your joints feeling good, protecting them,

(35:00):
Muscle signaling to your body, Hey we need this muscle.
That's also why you need to eat and focus on
protein because that's another signal to your body. We got
plenty of protein coming in. No need to break down
the protein we already have in our muscle.

Speaker 1 (35:15):
Yeah, that's a big part of this. It's almost like
you have to think of it almost like keto, where
you got to get your protein in. You know, you
got to eat that first and then go to the
charred broccolate which is also delicious.

Speaker 2 (35:28):
That's right.

Speaker 4 (35:28):
Protein and veggies. Yeah, that's where it's at. Stick around
there's more to come. How'd you get interested in this

(35:56):
line of doctoring.

Speaker 3 (36:00):
Was first of all, the surgery. You know, I started
as a barioatric surgeon or a weight loss surgeon, and
that was before these medications were around. These medications are revolutionary, Yeah,
because I never gave much credence to the prior classes
of obesity medications weight loss medications because they were so

(36:23):
ineffective compared to surgery. So for me, it's about, you know, results.
I'm like a New York guy, I want like the results,
and surgery was so impactful and so dramatic with the
weight loss that it could achieve. So I got into
it first because the surgery is really rewarding and technical.

(36:43):
You know, I only do minimally invasive surgery, laparoscopic surgery
through tiny holes with cameras, and lately robotic surgery, and
that kind of gets me going from a technical perspective,
I really enjoy that.

Speaker 2 (36:55):
That's like my zen, you know, when I'm in the oh,
are doing that?

Speaker 1 (36:59):
Is there a weight loss limit? Like there's the guy
on TV who specializes in over six hundred pound people? Yeah,
is there a limit that you say? You know, this
is too dangerous or I need you to lose weight
before well you're trying.

Speaker 3 (37:11):
Yeah, anyone who is in that five hundred plus category,
you want to encourage them and help them to lose
as much weight as possible. And you want to do
less risky surgeries like a sleeve than some sort of
bypass operation because it's like forty five minutes in and
out and get them off the table quick, right, and

(37:33):
then have them lose one hundred and fifty two hundred
pounds and then maybe do a bypass when.

Speaker 2 (37:37):
It's a little less risky.

Speaker 3 (37:40):
There are hospitals that specialize in those super super morbidly
obese patients.

Speaker 1 (37:46):
Yeah.

Speaker 3 (37:46):
I'm not a huge fan of that show. I think
it's a bit voyeuristic.

Speaker 2 (37:50):
For me. It's like a month in it's lumped in
with hoarders.

Speaker 1 (37:54):
Yes, they will. They pick people who you know, have
such obvious mental distress as well well, and they don't
really ever address that. And then that doctor's like, you know,
do hoopa do this today? You can't eat that, you know,
and he's yelling at them, and I think they're being shamed,
you know, And I mean I understand, like you're fighting

(38:15):
for your life. It's hard. It's hard when people say,
why don't you fight harder? You know, but sometimes people can't.

Speaker 3 (38:22):
Yeah, it's a real voyeuristic, objectifying show. I see him
at conferences sometimes, but I think he's doing good work.
I think he's helping a lot of people. I think
that surgery is extremely dangerous. If I can avoid operating
on someone that wight, I'd prefer to send them to
one of those super specialized hospitals. So I tend to
not take on cases that are that big. Yeah, but

(38:44):
it was also the transformation, Like surgeons don't necessarily love
being out of the operating room and that whole face
to face. We like our patients to sleep and covered
with blue drapes. Right, So so, but I really like
fell in love with watching that transformation happen in front

(39:05):
of my eyes over you know, three to six months
after surgery, and I found the stories amazing, the dynamics,
the changing of people's relationships. Yeah, someone got married because
the husband likes a woman who has low self esteem
and can't really handle when all of a sudden they.

Speaker 2 (39:24):
Get all of this attention.

Speaker 3 (39:27):
Right, Someone loses their friends because they were the funny
fat girl and that was their only role that their
friends could accept, you know, and talking to people about
this and being open about it and preparing them for
it was just really rewarding and fulfilling. And then these

(39:50):
meds came along and it's.

Speaker 1 (39:51):
Like changed a whole universe.

Speaker 2 (39:54):
It's changed everything in the last eighteen months.

Speaker 1 (39:58):
Now, what do you think about this controvert see about children?
You think children could benefit? I mean, I know when
you see a obese child, you know, my heart breaks
for them. Number one, at how hard it will be
to be in school and be teased and not able
to play sports. And I don't know, just it's so
overwhelmingly a negative future that awaits them if we don't

(40:22):
get it solved when they're a kid. Is there is
there anything? I mean? I know they don't test these
kind of drugs on children, and I've read some articles
about them that have strong opinions that kids should not
be on them. But what is your feelings?

Speaker 3 (40:38):
They definitely do test these drugs on children. Really, Wigovi
was approved for adolescents twelve to eighteen years old, and
they wouldn't make that approval without tons of data that
demonstrates safety, okay, and efficacy or that it works so

(40:58):
these medications at least ozembic slash wigovi, which is generically
known as semaglutide, has been approved for adolescents. And it's
a tricky area, especially in today's like political environment, to
talk about like medicating kids. You see all these laws

(41:21):
about healthcare for trans kids coming out.

Speaker 1 (41:26):
So scary and so horrifying. It's like, how did the
United States of America become this right?

Speaker 3 (41:33):
And trans kids go through so much as it is,
they're obese trans kids out there, and there's depressed trans
kids out there in the suicide rate, And would you
say that they couldn't have this medication to be healthier,
to socially be more accepted. I think the safety is

(41:55):
there to demonstrate a benefit. There have been studies for surgeries.
They've done lots of studies for obesity surgery on adolescent kids,
and it improves their health, it improves their quality of life,
it improves their social satisfaction. It gives this fork in
the road where someone can have their late teens and

(42:18):
twenties be so dramatically different. And if a fourteen year
old can get a nose job, why can't a fourteen
year old be put on this medication if the doctors
feel it's appropriate.

Speaker 1 (42:34):
Right, good point that those are a good point, you
know what, And you can't really walk in anyone else's shoes.

Speaker 2 (42:39):
Right, Yeah, you can't do comparative suffering.

Speaker 3 (42:42):
Right. If someone is suffering and this offers them a lifeline, yeah,
who are we to say they shouldn't have it?

Speaker 1 (42:49):
I agree? I totally agree. Well, listen, is there anything
you want to ask me before we go? That's been
a very interesting conversation and I'm hoping that we help
some people if they had questions.

Speaker 3 (43:02):
Yeah, I mean, I want to thank you for being
so open and honest. I think a lot of people
are afraid to admit they're on these medications.

Speaker 1 (43:11):
Why do you think that is.

Speaker 3 (43:13):
Because obesity bias? Because we love to hate people with obesity.
We don't hate people with high blood pressure, we don't
hate people with high cholesterol. We don't say they're weak
and blame them for their conditions. But because people have
to wear their disease out in public, they can be shamed.

(43:34):
And it's a kind of shaming where you don't get
to even get better, because if you're trying to get
better in any way except for that ingrained diet and
exercise nearly guaranteed failure route that's been shoved down our
throats for so long. Then you're taking a shortcut, right.
So it's like a damned if you do, damned if

(43:55):
you don't. It's a condemnation on our society. And I
think you part of the beginning of a change.

Speaker 1 (44:02):
Well, I certainly hope. So I think that you can have.
You know, listen, I look at Lizzo and I think,
good for her, you know, I think she's beautiful. I
look at her and I'm so inspired and so motivated,
and yet some little part voice and sign we goes,
oh no, don't she should cover that up? Oh no,
oh no, Right, I have to quiet that little voice

(44:25):
inside of me that you know that there's shame and
a roll of fat on your stomach, and look at
it on her. She embraces herself, She loves herself. I'm
wearing her bra and shorts right now from her yiddy line.
I bought all the stuff that they had because she
looks so great and everything, and I thought, let me
try to reframe what I think about myself. Let me

(44:47):
see if I can buy the stuff that she wears
and do it just for myself and my house and
my life. And you know, honestly, it's honey, wouldn't wouldn't
that be great if I could get a little lizzo.
I got to tell you that I'm very much of
a prude in some ways, I have to say, and
still kind of fat phobic about myself and you know,

(45:10):
not as much other people, but definitely about myself.

Speaker 3 (45:13):
Well, you hid it well because you advocate for so
many and like I've told you before, you're an absolute treasure.

Speaker 1 (45:21):
Oh, thank you so much.

Speaker 3 (45:23):
I hope you keep sharing your stories with people and
I appreciate.

Speaker 1 (45:27):
You and I think that you're great on the TikTok,
you're great on the Instagram. You a very loving, caring doctor.
And although I don't know you personally and I didn't
vet you, I just went on my vibes, and my
vibes are that you're a good guy and you know
what you're doing. Try thank you so much for being here,
and tell everybody where they can find you on TikTok

(45:48):
or Instagram.

Speaker 3 (45:49):
Yeah, doctor Daniel Rosen d R Daniel Rosen on TikTok
and Instagram.

Speaker 1 (45:54):
All right, thanks for being here. My pleasure, ay and
that was doctor Daniel Rosen. I hope that you enjoyed
that I'm trying to talk about feelings and facts and

(46:15):
the journey of obesity in America and weight loss individually.
If you have any questions, please drop us a voice
memo and next week the one and only sheil and Evans.
Google her. She's the most awarded woman in Hollywood period.
She's an expert at documentaries and ran HBO's documentary films

(46:36):
for many decades and now she's working at MTV. Eighty
four years old, smartest attack and one of my favorite
women on Earth. Sheilan Evans next week
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