This Episode is based on a comprehensive review article on therapeutic antiaging strategies (presented by MDPI, Basel, Switzerland). It explores aging as a progressive physiological process characterized by nine specific hallmarks, which are significant risk factors for various diseases. The review discusses different antiaging approaches based on these hallmarks, drawing on in vitro and in vivo research experiments. Strategies covered include anti-inflammatory drugs, antioxidant activity, telomere reactivation, epigenetic drugs, activation of the proteolytic system, mitophagy activators, inhibition of mTOR and insulin/IGF-1 signaling, activation of AMPK and Sirtuin signaling, clearance of senescent cells, stem cell-based therapies, the role of the microbiome, and noncoding RNAs. Ultimately, the article aims to highlight methods for promoting healthy aging and potentially extending human lifespan.
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Dateline NBC
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Amy Robach & T.J. Holmes present: Aubrey O’Day, Covering the Diddy Trial
Introducing… Aubrey O’Day Diddy’s former protege, television personality, platinum selling music artist, Danity Kane alum Aubrey O’Day joins veteran journalists Amy Robach and TJ Holmes to provide a unique perspective on the trial that has captivated the attention of the nation. Join them throughout the trial as they discuss, debate, and dissect every detail, every aspect of the proceedings. Aubrey will offer her opinions and expertise, as only she is qualified to do given her first-hand knowledge. From her days on Making the Band, as she emerged as the breakout star, the truth of the situation would be the opposite of the glitz and glamour. Listen throughout every minute of the trial, for this exclusive coverage. Amy Robach and TJ Holmes present Aubrey O’Day, Covering the Diddy Trial, an iHeartRadio podcast.
Stuff You Should Know
If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.