Midlife Mayhem

SLU-PP-332, 5-Amino-1MQ, and the Truth About Midlife Muscle & Fat

Hey friends, welcome back to Midlife Mayhem! I’ve just returned from a whirlwind trip through England and Greece—a mix of family remembrance, laughter, tears, chaos, and joy. I’m running on jet lag fumes, but I wanted to sit down and share something important with you today: two breakthrough compounds that could be absolute game-c...

We tend to think of the liver as “the detox organ.” We imagine green juice cleanses, detox teas, and vague ideas about “flushing toxins.” But your liver is so much more than that — it’s a powerhouse that affects every aspect of your body composition, from how much fat you store to how much energy you have.

And while the liver is incredibly resilient (it can literally regrow after being partially removed), modern lifestyles are push...

We’ve all heard the term GMO — genetically modified organisms — and most of us know it’s controversial. But there’s a newer, slicker technology making its way into our food supply that’s flying under the radar: gene editing. It’s marketed as “natural,” it’s not always labeled, and it’s already on supermarket shelves. The problem? Most consumers have no idea it’s there… or what it could mean for our health.

In this episode, I pull b...

If you’ve ever left Starbucks feeling bloated, sluggish, or… ahem… blocked up for days, you’re not imagining things. In this episode, I dive deep into why Starbucks hits your gut differently than your local coffee shop. From dark roasted beans and ultra-pasteurized milk to highly processed plant-based alternatives and the whole A1 vs A2 milk debate, I break down exactly what’s going on — and why it matters for your digestion, energ...

If you’ve hit a plateau with your workouts… if you're gaining fat despite training hard… or if you're feeling constantly tired and inflamed, your bloodwork might have the answers.

In this episode, we dive into:

• What the DHEA-to-cortisol ratio really tells you about stress, recovery, and resilience

• The exact numbers you want to see (with examples)

• Key blood markers like CK, AST, LDH, CRP, and what they reveal about muscle ...

Midlife Mayhem Podcast – Episode Title: "Midlife Thermostat: Why You're Sweating, Freezing, and Waking Up at 3 A.M."

Hosted by: Joanne Lee Cornish

In this packed episode, Joanne tackles one of the most frustrating but misunderstood midlife symptoms: temperature dysregulation. Whether you're a woman waking up drenched in sweat or a man with freezing hands and sleepless nights, your body's thermostat might be wo...

I have been meaning to do this podcast for months!

And although I am talking about men and testosterone, ladies please pay attention. Too many men are suffering in silence as their version of menopause (Andropause) is sneaky and subtle and often dismissed.

Testosterone isn't just about muscle or libido — it's the foundation of a man’s vitality, strength, confidence, and health. But what happens when it starts to decline… and how ...

🔥 JULY 4TH FLASH DEAL – ENDS MONDAY! Buy 1 bottle of 5-Amino-1MQ and get the 2nd for $100 – that’s a $39 savings! 🧬 Boost fat loss, protect muscle, and optimize your body’s performance. 👉 Use code JULY4 at checkout at www.5amino.com Expires Monday at noon (MST) – don’t miss it!

This episode is bold, necessary, and deeply personal.

We’re diving into the truth about HRT (Hormone Replacement Therapy) and HGH (Human Growth Hormone)...

This 28-day program is all about reclaiming food quality, reducing inflammation, and resetting your understanding of nourishment. It’s soy-, dairy-, gluten-, and added sugar–free. Learn more at www.tight28.com

In this episode, Joanne breaks down the two dominant eating models:

• Homeostatic Eating: eating driven by biological hunger cues

• Hedonic Eating: eating driven by pleasu...

🎙️ Midlife Mayhem Show Notes: Zonulin & Leaky Gut — Why You Can’t Not Be Affected

📆 Tight28 starts July 6–August 2! Enjoy your gluten-filled 4th of July… then join us for 28 days of discovery, education, and possibly the biggest physical and mental relief you didn’t know you needed. 👉 Tight28.com

In today’s episode, we’re getting real about z...

Tight28 starts July 6 — only offered once a year in LIVE format. This isn’t a gut reset or an elimination diet. It’s a discovery program for anyone who knows they don’t feel as great as they could. Join now → WWW.TIGHT28.COM

In this episode, Joanne takes a deep dive into a topic that's rarely discussed but highly impactful: histamine intolerance. Often mistaken for allergies or hormone issues, histamine overlo...

Join me for Tight28, starting July 6th – a deep dive into food sensitivities, inflammation, and organ health that could be the missing link in your journey to looking and feeling your absolute best.

Tight28 isn’t just a meal plan. It’s 28 days of discovery – uncovering how certain foods may be silently sabotaging your health, comfort, and body composition. This is the onl...

Tight28 is back July 6–August 2! If you’ve been feeling "okay, but not great," this program is for you. Tight28 dives into advanced topics like food sensitivities, inflammation, organ health, and how those invisible issues affect your weight, energy, bloating, joint pain, and even your mood—especially if you think you’re doing everything right.

💡 This is the only live round of Tight28 in 2025—and for so...

Tight28 starts July 6! This 28-day advanced program eliminates dairy, gluten, soy, and added sugar to reset your system, reduce inflammation, and finally move the needle on progress stalls. Learn more at 👉 www.tight28.com

In this thought-provoking episode of Mastering Midlife, Joanne Lee Cornish connects three powerful studies that shine a light on the psychological, metabolic, and societal complexities around food, dieting, and ...

👉 Next Program: TIGHT28 starts July 6 – Aug 2 A powerful 28-day body composition reset for anyone experiencing stalled progress, inflammation, bloating, or hidden food sensitivities. 💻 Learn more: www.tight28.com

Have you looked in the mirror and thought, "Where did my butt go?" You’re not alone — and today we’re diving deep into why glutes seem to vanish in midlife, and exactly what you can do to get them back ...

The Dates are now set for my next program TIGHT28 July 6 - August 2

Definition & Context

• Inflammation is a normal and essential immune response meant to be temporary and restorative.

• Chronic inflammation, however, is a constant internal stressor. It hijacks hormones, distorts metabolism, and impairs the body’s ability to burn fat effectively.

• This is a major reas...

If you’re a woman in midlife and just got lab results showing thyroid issues and a rising A1C, this episode is a must-read. Whether you’re premenopausal or postmenopausal, it’s more common than you think—and far too often misunderstood by conventional care.

Visit www.JLCstrong.com to explore my full library of self-study programs and subscribe to be notified when m...

“One day you’re fine… the next day you can’t hook your bra.” Welcome to the midlife mystery of sudden injuries—shoulder pain, hip twinges, numbness, plantar fasciitis, and everything in between. But here’s the truth: these injuries didn’t come out of nowhere.

In this episode, Joanne breaks down the hormonal, postural, and bi...

Episode Title: How Much Muscle Can You Really Lose? Host: Joanne Lee Cornish 📍 Listen on all platforms → www.jlcstrong.com 💊 My go-to compound → www.5amino.com

In today’s episode, I’m diving into a conversation that isn’t talked about enough, but it’s absolutely critical for anyone trying to lose weight—especially in midlife. We all talk about fat loss, scale victories, and appetite changes… but what most peop...