Midlife Mayhem

Midlife Mayhem Podcast

It’s Christmas week 🎄 and just a few weeks until my programs begin for the new year. If you’d like to see my full 2026 schedule, you’ll find it at:

👉 www.JoanneLee2026.com

📅 January 12–18

A powerful 5-day reset with:

• Coaching calls

• Structure

• Momentum

• Yes, weight loss — but so much more than...

In this episode, Joanne connects several conversations that are often discussed separately — facial fat loss, muscle loss, grip strength, hormones, and rapid weight loss — and explains why they’re all part of the same biological picture in midlife.

Rather than treating these changes as isolated or cosmetic issues, this episode explores what’s really happening underneath: estrogen decline, rising myostatin, changes in muscle quality...

Before we talk about December 31st, the FDA, or compounded weight-loss medications, this episode starts with something most people misunderstand:

What compounding pharmacies are actually for.

Joanne begins by explaining the original and ongoing role of compounding pharmacies — using hormone replacement therapy (HRT) as a clear, l...

Today’s episode was sparked by a Medscape article that immediately grabbed my attention. The headline essentially said that set point weight does not seem to decrease with the use of GLP-1 medications.

If you’re taking Semaglutide, Tirzepatide, or any of the current weight-loss medications, that line alone is enough to make your heart skip a beat. For many people, these medications have felt like the first time in their lives that ...

Testosterone therapy is exploding in popularity, especially among midlife women — but how you take testosterone dramatically affects how it works in your body.

In this episode, Joanne breaks down the three major delivery systems — transdermal creams, oral lozenges, and injections — and explains why some women are now being told they’re “poor absorbers” and switched to oral or injectable forms.

You’ll learn:

• Why women may not ...

In this episode of Midlife Mayhem, Joanne breaks down one of the most misunderstood concepts in the supplement and peptide world: half-life — the amount of time it takes for half of a substance to leave your system.

Half-life is the key that determines:

• how often you should take something

• whether a pill works better than an injection

• why weekly injections make sense for some compounds

• and why weekly injections are compl...

Joanne Lee Cornish explores two massive wellness categories — green powders and fiber supplements — breaking down real science, real efficacy, and real value. She helps you make informed decisions, avoid marketing fluff, and invest in what actually works.

• The manufacturing differences between whole-plant powders, juice powders, and cheap heat-dried powders

• Why processing method deter...

Most women only hear about PCOS in their teens or twenties — when cycles are irregular, acne is flaring, weight is piling onto the midsection, and fertility becomes a concern. But here’s the truth:

👉 PCOS does NOT disappear. 👉 Symptoms simply shift. 👉 And midlife can amplify everything that was simmering beneath the surface for decades.

...

In this episode of Midlife Mayhem, Joanne dives into one of the wildest cultural shifts in modern health and fitness: how we went from terrified of needles to injecting everything in sight — from weight loss medications to peptides, and now, even experimental compounds.

A few years ago, the idea of self-injecting anything was unthinkable. Today?...

“Sore but Not Growing: Why Pain Isn’t Proof of Progress”

We’ve been taught to wear soreness like a badge of honor. If you can’t sit down after leg day, that’s proof you “did it right,” right? Wrong.

Soreness is inflammation — not progress. It’s a sign your muscles are repairing micro-tears, not necessarily adapting or growing stronger. In fact, constant soreness can be a red...

“Hormones Off the Hook: What the FDA’s New Decision Means for Women, HRT, and the Future of Menopause Care”

For decades, women have been warned that hormone replacement therapy (HRT) is risky business — linked to heart disease, cancer, and every imaginable midlife horror story.

But that narrative just flipped.

In a landmark move, the FDA has lifted the black box warnings from many HRT product...

Rewriting My Midlife Brand, Metabolism & Fasting: Why I’m Becoming JoanneLee.com

Episode Description In this episode, I pull back the curtain on a big shift: after 30 years as The Shrink Shop, I’m moving everything under JoanneLee.com and fully owning the work I actually do — high-level body composition and midlife coaching that goes way beyond “just weight loss.”

We’ll dive into why I’m rebranding, how my coaching has evolved...

Most women are never told what to expect as they approach menopause. There’s no handbook, no clear roadmap — just years of confusion, self-blame, and frustration as symptoms slowly appear. It’s heartbreaking that we enter one of the biggest biological transitions of our lives unprepared — often told to “just get on with it.”

In this episode, Joanne breaks down the menopause journey — a stage-by-stage guide explaining what’s happeni...

We’ve all heard the phrase “The mitochondria is the powerhouse of the cell” — probably in high school biology, on a meme, or even on a T-shirt. But what most people don’t realize is that this isn’t just trivia. This is the foundation of how you age, how you feel, and how your body performs every single day.

In this episode, Joanne breaks down what cellular health really means — in plain English — and why the...

Why the FDA Reclassified 17 Peptides — and What It Really Means”

The headlines said the FDA “banned 17 peptides.” But the truth? It’s not a sudden ban — it’s the inevitable fallout of peptides becoming too popular for their own good.

In this episode, Joanne Lee Cornish breaks down what really happened in July, why it started with the GLP-1 explosion, and how the FDA’s new classification is reshaping the pept...

Episode summary Your waist isn’t just “aesthetic”—it’s a metabolic dashboard. In this episode, Joanne breaks down why central fat (especially visceral fat) screams insulin resistance, tanks testosterone in men, drives unfavorable estrogen dynamics in women, and turns up the dial on inflammation, fatty liver, and long-term disease risk. You’ll learn simple ways to measure risk a...

👉 Mastering Midlife starts this Sunday! This is my most in-depth program of the year, and inside we’ll cover everything from hormones to metabolism to why weight loss feels harder in midlife. In this episode, I’ll also give you a sneak peek into one of our topics: plateaus—why they happen, and what to do when your body stalls. If you’re ready to finally understand your body in midlife (instead of fighting it), join us at www.midli...

Episode Title: Why the WHI Study Still Misguides Midlife Women + Why Birth Control Isn’t Hormone Therapy

Mastering Midlife starts on SUNDAY (Sept 21) www.midlifemonth.com

In this episode of Midlife Mayhem, Joanne Lee Cornish breaks down one of the most damaging studies in women’s health history—the Women’s Health Initiative (WHI)—and explains how its flawed design still shapes the way doctors approach hormone rep...

Welcome to Midlife Mayhem! For the first time, I’m not just talking to you through your headphones — I’m also filming this for YouTube. So if you’d rather see me chatting through today’s episode, head over to (joanne lee cornish)  my YouTube channel. 

Today, I want to share some of the lesser-known supplement pairings I personally use and keep on hand. These aren’t your typical multivitamins or fish oils — they’re unique stacks tha...