GasGasGas - Anaesthetic Science for Anaesthesia!
An Anaesthesia Podcast focusing on the science knowledge anaesthetists should know. We track the UK Primary FRCA Curriculum. > GasGasGas will fit into a corner of your day, delivering a treatise on a drug, concept or practice critical to the knowledge required to pass the FRCA Primary Exam! > There are naturally tangents, as hearing a word vomit of data with no joy is not the aim of Dr gas! > This is relevant to anyone in the world interested in these pharmacological, physiological, clinical, physical and chemical concepts, > Notes on https:/gasgasgas.uk > Sponsored by Teach Me Anaesthetics SBA Resource All content is my personal opinion, not medical advice and is never a substitute for formal education / training. © GasGasGas – The FRCA Primary Anaesthetic Sciences Podcast 2025
Episodes
Anti-Cholinesterases, they find widespread use in clinical medicine.
Their role in reversal of neuromuscular blockade is certainly dwindling given sugammadexes rise to post patent [can actually afford to use it] supremacy.
But if you are using atracurium, then go nuts!
Listen to find out more!
Show notes at : https://gasgasgas.uk/anticholinesterases/
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GasGasGas - Covering Anaesthetic ...
Sugammadex, if Carlsberg made Sugammadex, it might just be the best drug in the world.
I.e. if you were to describe a perfect neuromuscular reversal drug, sugammadex is getting very close!
Listen to find out more!
Show notes at : https://gasgasgas.uk/sugammadex/
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GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach me Anaesthetics
Pancuronium pandemonium, with a dash of Type 1 and Type 2 Block for good measure.
Listen to find out more!
Show notes at : https://gasgasgas.uk/pancuronium/
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GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach me Anaesthetics
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
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Vecuronium for anaesthetists with a segue into NMJ/MNB monitoring!
Listen to find out more!
Show notes at : https://gasgasgas.uk/vecuronium/
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GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach me Anaesthetics
Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate]
Contributions to keep the lamps lit here
=======================================...
Cisatracurium is one of the ten isomers found in an ampoule of Atracurium! It has been selected out as a useful, potent, predictably degrading drug with a very stable side effect profile!
Althought, it might be that, whilst Cisatracurium probably sounded like a great idea at the time... it was perhaps batting for a marketing USP that wasn't quite there..
If we were being particularly clever we could call it the R-cis-R'-cis isomer ...
Mivacurium, a drug that is perhaps not found in your cupboard anymore! It does have a number of interesting properties, which does make it a worthy exam question and a useful example of geometric isomerism!
Listen to find out more
Show notes at:https://gasgasgas.uk/mivacurium
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GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach me Anaesthetics
The ubiquity of oxygen in the curriculum is directly correlated with its importance! One of many episodes that focus on the facets o knowledge needed to understand how oxygen does its thing. Today, when too much oxygen is a bad thing, how it is obtained, transported in hospitals and the negative implications of its use + some history that I know you all deeply desire!
Show notes at: https://gasgasgas.uk/oxygen-for-the-frca-primar...
Nitrous Oxide, once a corner stone of 'passing the gas' has been progressively displaced by better agents, think sevoflurane with less PONV, remifentanil for rapid titratable pain relief and even desflurane for its speedier offset.
This episode handles everything you need to know and more for the exams!
Show notes at: https://gasgasgas.uk/ether_enflurane_explosions/
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GasGasGas - Cover...
The 2025 Bumper Christmas Special, delving into the delights of Ether, Enflurane and Explosions (+ fires, flames and/or power metal)
We find out a little bit about the first Ether anaesthetic, and then get to grips with what an explosion is, and why understandably, it was problematic for anaesthetists.
Show notes at: https://gasgasgas.uk/ether_enflurane_explosions/
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GasGasGas - Coveri...
I've checked the house, there are no polar bears so we should be fine to talk about this drug.
Desflurane is pricey, polar bear poison that you may get examined on! Check it out!
Show notes at: https://gasgasgas.uk/desflurane-and-vapourisers/
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GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach me Anaesthetics
With the advent of halothane, smoking, static and other sizzling was back in style! Gone were the explosive diethyl ether, acetylene, trichloroethylene and cyclopropane anaesthetics of the 1950's and with it a new era of fewer explosions, and possibly a greater prevalence of post operative liver distress.
Show notes at: https://gasgasgas.uk/halothane/↗
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GasGasGas - Covering Anaestheti...
Having a solid understanding of Sevoflurane is, as you might expect, quite important for the FRCA primary and your career. as it is likely the most commonly used volatile anaesthetic agent, at least in the UK.
Show notes @ https://gasgasgas.uk/sevoflurane-for-the-frca-primary/
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GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach Me Anaesthetics
This Primary FRCA podcast episode introduces you to Isoflurane, a ubiquitous and fairly cheap volatile anaesthetic agent that always seems to be left alone while its sevoflurane friend lives the high life, This episode probably won't sway your use, but if you walk into an anaesthetic halfway thru and have no idea what your ET for MAC-1 is, then this is for you!
GasGasGas - putting knowledge in your brain!
Show notes at: https://gas...
This Primary FRCA podcast episode introduces you to Volatile anaesthetic agents and the pharmaceutical particulars that make their behaviour through a human very interesting!
We cover Blood gas and oil gas partition coefficients, Saturated vapour pressure, critical temperature and boiling points - and touch on pharmacodynamics and the Viva Question 'What is the ideal anaesthetic agent' approach.
Show notes at: https://gasgasgas.uk/...
Yet again, the sound engineer has been sacked........
- Apologies that this is a second attempt at an Opioids Quiz, the music cuts went rather wrong - so we've slung the music in the bin!
- This is a straight up quiz, with gaps so you can think up an answer and then, as you might expect... an Answer!
- The goal isn't to give you verbatim words to regurgitate but to build up these facts in your mind so then next time you cover it you...
Clonidine is a drug found in many a cupboard, acting as a useful adjunct for pain, sedation and having utility in smoothing out post op emergence, it has off license use as a adjunct in regional and neuraxial blockade (at least in the literature!)
Show notes at: https://gasgasgas.uk/clonidine/
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GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach Me Anaesthet...
Dexemedetomidine is a drug that it seems we are really only just getting our hands on in the UK, it is an Alpha 2 AGOnist causing sedation, anxiolysis and analgesia.
This episode of GasGasGas explores its use, mechanisms side effect profile and kinetics
Show notes at: https://gasgasgas.uk/dexmedetomidine/
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GasGasGas - Covering Anaesthetic Science for Anaesthetists!
Sponsored by Teach...
Midazolam represents the cornerstone benzodiazepine in perioperative medicine, offering rapid onset sedation, anxiolysis, and amnesia with predictable pharmacokinetics. Understanding its mechanism, dosing strategies, and clinical applications is fundamental for safe anaesthetic practice and optimal patient care.
Show notes @: https://gasgasgas.uk/midazolam/
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GasGasGas - Covering Anaes...
Having an Iota of a Scooby-Doo about Etomidate is perhaps what is required for the FRCA primary exams. We've gone into naturally more detail when we're talking Etomidate for gasgasgas, because we love a bit of detail. This episode covers the pharmacodynamics and pharmacokinetics of Etomidate, but also explores briefly steroidogenesis and what the implications of this is clinically.
GasGasGas - putting knowledge in your brain!
Understanding molecular stereochemistry is fundamental to modern anaesthetic practice. The three-dimensional arrangement of atoms within drug molecules directly impacts their pharmacological properties, with some arrangements being therapeutically beneficial while others may be inactive or even harmful. This episode explores the concept of isomerism in anaesthetic drugs, with particular focus on how molecular handedness affects dru...
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