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April 25, 2025 16 mins

In this episode, Dr. Daniel Durand, Chief Medical Officer and President of Prenuvo, discusses how their whole-body, non-invasive MRI technology is transforming proactive healthcare. He shares insights on early disease detection, the patient experience, and the evolving role of prevention in modern medicine.

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Episode Transcript

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(00:00):
This is Gracelyn Keller with the Becker's Healthcare
podcast, and I am excited to be joined
today by Daniel Durand, who is the CMO
and president at Pranuvo.
So, Daniel, thank you so much for joining
me today. I'm very interested to hear more
about what Pranuvo is and how patients are
using it today. So let's start our conversation
today by having you introduce yourself and telling
us a little bit more about Prenuvo.

(00:22):
Absolutely. Well, I've transitioned to become chief medical
officer and president here at Prenuvo,
and Prenuvo is one of the brands and
one of the companies that's leading the wellness
and proactive
health care revolution. We are the world's largest
set of clinics exclusively dedicated to doing full
body MRI for preventative purposes.

(00:42):
And our idea
and our principle is we wanna find, the
earliest possible
signs that a patient is sick or has
an illness that might hurt them. But beyond
that, we also want patients to deeply understand
their health and be able to optimize their
health before they get
sick. So that's that's really what we're about,
and we are, clinics all throughout The United

(01:03):
States,
some in Canada, and then also are expanding
to other countries,
as we speak.
Well, thank you so much for taking the
time to be here today, and let's dive
in with just having you explain a little
bit more about what exactly the company does.
Well, we what we do is we in
the least invasive way possible and the least

(01:26):
producing zero harm, we extract as much information
as we can from the human body, and
we do this with non contrast MRI. We
essentially digitize
a patient.
We put them in a scanner, and over
the course of about forty minutes, we obtain
1,300,000,000
data points about their body.
And this then becomes images, which are analyzed

(01:46):
by a combination of,
in some of the products, artificial intelligence, but
in all the products, a board certified
trained radiologist
that will look through all of their images
in a very, very systematic fashion and determine
what is normal and what is abnormal.
And then the results of that, they go
directly to the patient

(02:06):
in very patient forward,
lay terms into their application
on their phone, and they instantly get access
to all of their images. But in addition
to that, they will get a full, debriefing
session
to, explain their results to them from a
licensed provider,
either a primary care doctor, a physician, or
a nurse practitioner.

(02:26):
So it's really a full,
I would say, micro continuum of care.
And because we're doing this without contrast,
nobody,
sticks a needle or does anything to the
patient. The only thing the patient has to
do
is let us know why they're seeking the
exam so we can turn determine if it's
appropriate,
confirm that they're over the age of 18
because we don't do pediatrics,

(02:47):
and then eventually fill out a medical form
and come in and get the scan done.
They they lie down. They go into a
a wide bore MRI machine.
They're outfitted with mirrors so they can actually
watch music and and, listen to music or
watch TV
while they're in there.
So as these things go, it's one of
it's the most comfortable MRI I've ever personally
been in, and we get pretty rave reviews

(03:09):
for it and have very low claustrophobia
type,
you know, anxiety in this MRI versus others.
But really that that, chance of claustrophobia
is the only downside to getting the scan.
There's no radiation. There's no needles. And so
people report it as a very, very pleasant
experience. And then they go home, and and
as I said, we then have the radiologist
read it and someone gets in touch with

(03:30):
them with their results. They're free to call
back in if they didn't understand the first
time. They were told they're,
free to get their images and bring them
to their physician.
We will talk to their physician if they
have one.
And so that's the model is to gather
data noninvasively.
And there's really three things, that can be
done with this data. The first thing is
the obvious thing. We can tell if a
patient is sick often before they have symptoms

(03:51):
or before their doctor or other tests could
tell that they were sick. And this is
true for things that are silent killers like
aneurysms
and cancers, and, you know, some but not
all cancers are things that we can see
quite early.
And then there's many other physician, conditions that
that things,
people don't necessarily think of first with us.
Things like fatty liver disease,
inflammatory bowel disease, spinal diseases, neurodegenerative

(04:14):
conditions like MS. So we can see see
many things quite early,
and that's a good reason to come to
us. The second reason is that people can
understand where their health is. So not just
understand what diseases might be present,
but where their health is. So what their
body composition looks like and what the meta
metabolic markers that we can see on MRI,
what that

(04:36):
means about where they are relative to age
adjusted norms to give them a sense for
how their current state of health is.
And then the last piece, the third thing
is we can follow people over time so
we can give them insight into how they're
aging in terms of their spinal age, their
joints, and things like that. These are things
we're doing more today on a research perspective,
but we hope to offer products in the

(04:57):
future that can give people a sense of
where they are on aging curves organ by
organ and then collectively.
And those longitudinal
aspects also allow people to look at that
baseline state of health that we've described upfront.
Let's say they had fatty liver disease
and then see where those biomarkers are after
they've taken certain lifestyle interventions or maybe medications

(05:19):
like GLPs.
And so this whole thing is a continuum
of understanding the baseline state of disease, health,
and then optimizing
for health.
So, Dan, I would love to hear more
about your experience specifically.
My experience, I'm a middle aged male,
fairly healthy. I'm 45 years old, and I,

(05:40):
have the the only thing I really have,
that's a preexisting condition is
high cholesterol.
So for me, this is a good test
to get ahead of my health. And I
have, like most people, I don't love lying
in tight spaces, but I'm not
overtly claustrophobic, and I've done this sort of
thing before. So for me,
it's a very pleasant experience. I fasted for

(06:01):
four hours. I went into our center at
Bethesda.
I was greeted. I filled out my medical
intake form. And since it was the second
time I'd been there, they gave me this
iPad, and I was able to just sort
of say yes and make a few changes
to the things that had happened to my
health from the prior year when I got
my scan.
And then, we went to the changing room,
was shown in the changing room that's in

(06:22):
Zone 2 of the MRI. So,
you have to be let back there, and
it's a nice spacious changing room. And I
put on the Pranuvo scrubs, and then my
MRI technician came, and he, made sure I
was safe from the for the exam by
asking me the standard questions about surgeries or
metal implants.
Again, even though I had given that information
before, we do these checks right beforehand just

(06:43):
like in the aviation industry to make sure
everybody's safe.
They then ran me by
a state of the art metal detector to
make sure that even if I had accidentally
brought some metal in, that it wasn't on
me. And then I was shown into Zone
3, which is the control area.
And he then walked me through that into
the MRI machine itself.
Laid down the table very comfortable, and then

(07:04):
they put you back into the scanner. I
usually spend most of my time in there,
just kinda listening
and,
you know, sleeping because I I have an
infinite home, so it's an hour that I
can sort of get caught up on sleep.
But, you can also if you open your
eyes, you can see the TV. As you
kinda go back into
the tube. There's a set set of mirrors.
And as you get to the back of

(07:24):
the tube,
which is normally where you'd feel the most
confined, it actually opens up because the mirrors
reflect the space that's just
above your head, and it shows you, an
LCD TV screen that's safely outside the MRI
zone, but you can see the image. And
so you can do things like stream your
favorite shows while you while you're in this
machine. But I personally like to use it

(07:45):
as a time for reflection.
So after about an hour because I got
the enhanced scan with a couple of new
additions to it, I was done, and then
I went home. And, actually,
later today, like, one of my I'll be
having my consultation with the the physician at
the at the end of this,
the process. So
but I they've already communicated my results and,

(08:06):
you know, through the app, which were
there was no alarming findings and so more
good news and reassurance from Pranuvo for me
personally.
Wonderful. And I'm sure it's it's really nice
to have, you know, that
information
because
if you don't know what's wrong, you can't
understand how to fix it. And also, you
know, to know that you are healthy, that's

(08:27):
that's wonderful news to have.
I would love to know what you would
say to somebody who
is interested or maybe
knows that this could be a good opportunity
for them to explore deeper in their health,
but they don't feel like they need to
do so because they are already have a
clean bill of health.
Well, the the clean bill of health that

(08:48):
that they have, it really depends on how
they arrived at that. Right? So if if
a clean bill of health for some people
means you've been to your physician and they've
sort of looked you over on the outside,
I think that's that's great. Like, we would
say do that first. Right? We we are
not trying to replace
all the standard screenings or, and we're trying
to enhance and not at all replace a
patient's sort of sacred relationship

(09:09):
with their primary care provider.
However,
all primary care providers will freely admit that
there are real limitations to their exams. And
one of our business biggest growing areas of
our,
of our business and what we do is
primary care doctors referring patients to us. Right?
And the reason for that is I think
a lot of primary care doctors recognize the

(09:30):
limitations of the physical exam. By the time
you can see something on the outside of
your body, unless that's something relates to
the organ on the outside of your body,
which is your largest organ in your skin.
But if it relates to any other organ,
you'll see it better on the inside. And,
almost any disease process eventually impacts what we
call our soft tissues. And our soft tissues,

(09:52):
things like the liver, the spleen, etcetera, the
pancreas, these are the things that MRI sees
better than any other type of imaging.
And then fortunately, it doesn't have any radiation.
So you can actually use this as a
looking glass, as a kind of
Superman type microscope or something and let a
doctor see through you and give you that
physical exam on the inside. And this is
really what we are. We're not a test.

(10:14):
We are, a we're a a tech enabled,
direct to specialist
health care model.
And the health care is virtual because you
get digitized in the scanner, and then a
radiologist looks through you voxel by voxel. You
know?
And it it there's nothing else that's quite
like it, but it's the best way to
think about it is like a physical exam
on the inside of your body. And so

(10:35):
that clean bill of health that somebody thinks
they've had because they've had someone look at
the outside of their body,
there's a deeper level reassurance. It doesn't replace
the other thing. Right? But if you add
this to it, I would say I personally
received a a deeper layer of reassurance.
And some of the data that we're starting
to publish now, I think, bears that out,
that that the negative predictive value of this

(10:55):
experience. In other words, if you don't have
any alarming findings,
you know, what your health outcomes will look
like, they're they're quite good, and I can
share some of that if if you're interested
to to hear more.
Yeah. Absolutely. No. What you said makes total
sense.
And it's very true when you go in
for a physical beyond blood work. There's not
really much that they do to look internally.

(11:18):
So I appreciate that response.
And I would love to know as you
look into the next
year and even beyond,
what do you think is in store for
Pranuvo, and how can or how do you
see the evolution of this continuing over time?
Prenuvo is part of a broader shift away
from reacting to to to illness and

(11:39):
towards being proactive,
dealing with illness early on or even preventing
it. And from a biological perspective, it's kinda
like the difference between
studying and understanding health and trying to maintain
health
through the processes of aging, right,
versus
really just kinda standing by waiting to sort

(11:59):
of see disease early, but really mainly responding
to disease. And there's a very big difference
between the two. And and we're not the
only company out there doing this sort of
thing, either within whole body MRI or more
broadly
within proactive care. And so that's the revolution
that's happening. And I think what you'll see
more of is more and more noninvasive
or minimally invasive data gathering, because that is

(12:21):
how, whether it's the blood labs you described
or the whole body MRI that I described,
by gathering more information,
that's how we're gonna better understand health. I
I've been to medical school. I've taught at
medical school. I'm a pretty curious person. You
know, you might call me a voracious reader
and and learner. And
there's not much of my brain that has

(12:41):
been taught about health relative to disease. Like,
I'm really getting into that and have been
the last few years. But when you go
to medical school, they mainly teach you about
disease. You learn the basics of anatomy, but
you don't learn a lot about a state
of health and the differences in different types
of states of health. You don't learn a
lot about optimizing health. You learn almost entirely
about dealing with disease when it happens.

(13:02):
And it's kinda like the difference between fixing
your car when it breaks or when there's
smoke coming out of the hood, right, versus
taking that car proactively to the shop every
time you hit whatever milestone that the car
dealer has told you about, whether it's 15,000
or 30,000.
Human beings are not cars, but we're we
are complex systems.
And we we start to approach our expiration

(13:24):
date from our late twenties forward. About '27
is when people are,
done growing and forming, and that's after that,
it's aging. And
what you wanna do after that age point
is really maintain that state of health and
optimize it for as long as you can
and avoid chronic and acute diseases if possible.
So, Dan, how do hospitals and health systems

(13:46):
kind of fit into this picture?
Well, thanks, Grace.
The the way that we interact with the
rest of the health care ecosystem, I would
say, is still evolving. Generally speaking,
we diagnose or we detect
conditions. And after that, we're trying to connect
patients to care. And so we're presently building
a collaborative network,

(14:07):
which we're hoping to call the Pranuvo Care
Network. And so if there are health systems
out there that are interested in providing access
to patients
who have proactively taken,
the measures to to find out if there
if there's,
an issue for them to deal with. About
one in twenty of those patients or five
percent, they're they're gonna get news back that
there is something that they need to see

(14:27):
a doctor for often, fairly quickly. And so
getting access for those patients to the best
possible, centers that know what to do with
that type of imaging information,
that's the goal of this network. And if
others,
if there's any health system leaders out there
to whom this sounds intriguing,
we are happy to partner with, with them.
And, really, what we're trying to do, as

(14:48):
I said before, we're trying to enhance and
and go on top of everything else that's
out there. We are not trying to replace
or frankly compete with any part of the
existing,
legacy health care system.
Absolutely.
And, Dan, where can people learn more about
Pranuvo,
if they're interested in incorporating this into their

(15:09):
their yearly or annual, you know, checkups on
their wellness?
Website's a great place to start. Www.prenuvo.com.
We're we're pretty optimized on search. If they
just search for prenuvo, they'll find us as
well.
We have great information there on the patient
side of that website that talks about, what
we do as well as the testimonials and

(15:30):
what patients think of us. And, you know,
we're very proud of the the the sheer
number of of great stories that folks have
about life saving findings and also,
sometimes often just reassurance. You know? And,
we think there's real value in both sides
of that.
Wonderful. Well, Dan, thanks so much for taking
the time to join me today on the

(15:51):
Becker's Healthcare podcast and share about PENUBO and
just this increasing trend of moving from, you
know,
reactive to preventative,
I think it's a really important topic that
we're only gonna see continue to grow. So
thank you so much for joining me today.
Absolutely. Thank you, Chris.
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