MDS Podcast

MDS Podcast

Stay up to date on novel, clinically-relevant research findings in Parkinson's disease and other movement disorders. Each episode of the International Parkinson and Movement Disorder Society podcast discusses a relevant development in the field, including highlighted journal articles and interviews with the authors.

Episodes

Special Series: Myoclonus new classification & treatment

April 21, 2025
Prof. Marina de Koning-Tijssen interviews Prof. John Caviness on the topic of myoclonus, focusing on its new classification and treatment. They discuss the long-awaited recently published classification of myoclonus and explore the latest treatment options.
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Celebrating the Parkinson's community

April 11, 2025
On this special World Parkinson’s Day episode, Dr. Michele Matarazzo is joined by John Dean—speech-language pathologist and Chair of the MDS Allied Health Professionals Group—to explore the essential roles of care partners, allied health professionals, and the broader Parkinson’s community. From physiotherapists to family members, we shine a light on the many people who support those living with Parkinson’s disease every day. Worl...
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Gender differences in DBS decision making

April 7, 2025
Dr. Sara Schaefer discusses with Dr. Michelle Fullard the similarities and differences in how men and women with Parkinson's disease approach the decision of whether or not to undergo deep brain stimulation. Read the article.
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Special Issue: GLP-1 agonists in Parkinson’s disease: New evidence, new questions?

March 31, 2025
In this episode, Dr. Michele Matarazzo interviews Prof. Tom Foltynie about the recently published phase 3 clinical trial of exenatide as a disease-modifying therapy for Parkinson’s disease in The Lancet. While the findings were disappointing, ongoing post-hoc analyses aim to understand the discrepancy with previous phase 2 results and explore how they might shape the future of exenatide and other GLP-1 agonists in neurodegenerative...
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Mitochondrial DNA copy number: A potential biomarker for Parkinson's disease progression

March 24, 2025
Prof. Sarah Camargos interviews Prof. Sun Ju Chung about his recent paper in the Movement Disorders Journal investigating diagnostic and prognostic capabilities of measuring blood mitochondrial DNA copy number (mtDNA-CN) for Parkinson’s disease.
Journal CME is available until March 3, 2026 Read the article.
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tDCS for Tourette syndrome

March 17, 2025
Dr. Sara Schaefer and Dr. Davide Martino discuss his recent paper exploring the use of transcranial direct current stimulation over the supplementary motor area for the suppression of tics in patients with Tourette Syndrome. Read the article.
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Are hyposmia and REM sleep behavior disorder reliable indicators of Lewy body pathology?

March 10, 2025
There is an important role for cost-effective clinical biomarkers in the diagnosis of Parkinson's disease. Dr. Eduardo de Pablo-Fernández and Dr. Cecilia Tremblay discuss how accurate hyposmia and REM sleep behavior disorder can predict Lewy pathology in a non-selected population using data from the Arizona clinicopathological study on Aging and Neurodegeneration. Read the article.
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Combined habit reversal and acceptance and commitment therapies for tics

March 3, 2025
Dr. Jennifer Eisenhauer joins Dr. Sara Schaefer to discuss her recent article describing a combined therapy approach for adult patient with tics: habit reversal therapy (HRT) + acceptance and commitment therapy (ACT). They further discuss what these therapies are, their effect in tics, what is gratifying about working with patients with tics, and next steps to determine efficacy of this approach. Read the article.
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Immune, metabolic and tau markers in blood cells in progressive supranuclear palsy

February 24, 2025
Dr. Eduardo de Pablo-Fernández and Dr Tommaso Schirinzi discuss the results of his study evaluating markers of immune response, metabolism, inflammatory regulation and tau levels in blood cells in patients with progressive supranuclear palsy (PSP). They also discuss how these results contribute to the growing evidence of neuroinflammation contributing to the pathogenesis of PSP.
Journal CME is available until October 21, 2025...
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Focused ultrasound for cervical dystonia

February 17, 2025
Dr. Shiro Horisawa discusses the latest clinical trial results on MR-guided focused ultrasound pallidothalamic tractotomy for cervical dystonia. He explores the technique's limitations, future prospects, and how it compares to existing therapeutic options. Read the article.
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Hot Topic: Subcutaneous levodopa infusion

February 10, 2025
Dr. Hugo Morales Briceno interviews Prof. Ray Chaudhuri to discuss the real world-use of levodopa subcutaneous infusion in patients with Parkinson's disease.
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Vibrotactile foot stimulation for freezing of gait

February 3, 2025
Dr. Chan joins the podcast to discuss the results of their pilot study with Dr. Eduardo De Pablo-Fernández. The study uses a foot vibrotactile stimulation as an external cue for the treatment of freezing of gait in Parkinson's disease. Together they discuss how vibrotactile devices can be implemented in clinical practice. Read the article.
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Video-based machine learning for tic detection

January 27, 2025
In this episode, Prof. Alexander Münchau talks about how machine learning video-based assessments can be leveraged to quantify tics in Tourette syndrome and how this technology has the potential to assist clinicians in tic detection. Read the article.
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Special Series: What's in store? The future of tremor research

January 20, 2025
In this episode, Dr. Aasef Shaikh and Dr. Ming-Kai Pan give us a virtual guided tour of their labs, particularly discussing what they are presently working on. They further elaborate on how these studies can inform our understanding of tremor physiology and where they believe the field should be heading in order to finally understand tremor origin.
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Defining Parkinson's disease: where we are, where we are headed

January 13, 2025
Dr. Michele Matarazzo interviews Dr. Victor Fung, President of the International Parkinson and Movement Disorder Society and lead author of the recent viewpoint published in the Movement Disorders journal. Together, they explore the biological definition and classification of Parkinson's disease, discussing its key insights, future prospects, and the implications of recent advances in the field. Read the article.
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Special Series: The novel pharmacological and surgical treatments for tremor

January 6, 2025
In this episode Dr. Ludy Shih briefly describes the current approach to tremor, including pharmacological treatments, botulinum toxin injections and deep brain stimulation. She further dives into the exciting new developments of the past few years and new drugs coming down the pipeline.
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Special Series: What’s essential tremor?

December 16, 2024
In this episode, the two souls at the center of the new tremor classification join the MDS Podcast to discuss what essential tremor is. Listen as Prof. Kailash Bhatia and Prof. Günther Deuschl walk you through their clinical methods and future outlook on essential tremor. Do they agree? Disagree?
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Skin tau as a biomarker of Huntington's disease

December 6, 2024
Growing evidence suggests a contributory role of tau protein in the pathogenesis of Huntington's disease. In this episode, Dr. Eduardo de Pablo-Fernández discusses the potential role of skin tau quantification as a biomarker for Huntington's disease with Dr. Jaime Kulisevsky and Dr. Iñigo Ruiz-Barrio. The authors discuss the results of the recent study correlating skin tau quantification with clinical and radiological data, and the...
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Special Series: So common, so difficult: The phenomenology of tremor

December 2, 2024
In this episode Dr. Alfonso Fasano interviews Dr. Petra Schwingenschuh on her approach to tremor in the clinic. She further explains the importance of a good history taking, how to clinically assess tremor of different body parts, and how to diagnose functional tremor.
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World Movement Disorders Day: Stigma in pediatric movement disorders

November 27, 2024
Dr. Sara Schaefer interviews Dr. Jaclyn Martindale on stigma in the experiences of individuals with pediatric movement disorders and tic disorders. They discuss the reasons behind stigma, types of stigma, and ways that stigma is perpetuated and mitigated in this special episode for World Movement Disorders Day 2024.
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