Talk Python To Me
Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.
Episodes
April 21, 2025 • 63 mins
Do you or your company need accounting software? Well, there are plenty of SaaS products out there that you can give your data to. but maybe you also really like Django and would rather have a foundation to build your own accounting system exactly as you need for your company or your product. On this episode, we're diving into Django Ledger, created by Miguel Sanda, which can do just that.
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April 14, 2025 • 60 mins
Have you ever spent an afternoon wrestling with a Jupyter notebook, hoping that you ran the cells in just the right order, only to realize your outputs were completely out of sync? Today's guest has a fresh take on solving that exact problem. Akshay Agrawal is here to introduce Marimo, a reactive Python notebook that ensures your code and outputs always stay in lockstep. And that's just the start! We'll also dig into Akshay's back...
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April 10, 2025 • 57 mins
We're sitting down with Eric Matthes, the educator, author, and developer behind Django Simple Deploy. If you've ever struggled with taking that final step of getting your Django app onto a live server (without spending days wrestling with DevOps complexities), then give Django Simple Deploy a look. Eric shares how Django Simple Deploy automates away the boilerplate parts of deployment, so you can focus on building features instead...
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March 31, 2025 • 67 mins
This episode is all about Beeware, the project that working towards true native apps built on Python, especially for iOS and Android. Russell's been at this for more than a decade, and the progress is now hitting critical mass. We'll talk about the Toga GUI toolkit, building and shipping your apps with Briefcase, the newly official support for iOS and Android in CPython, and so much more. I can't wait to explore how BeeWare opens u...
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March 24, 2025 • 68 mins
In this episode, we welcome back Will McGugan, the creator of the wildly popular Rich library and founder of Textualize. We'll dive into Will's latest article on "Algorithms for High Performance Terminal Apps" and explore how he's quietly revolutionizing what's possible in the terminal, from smooth animations and dynamic widgets to full-on TUI (or should we say GUI?) frameworks. Whether you're looking to supercharge your command-li...
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March 21, 2025 • 55 mins
Have you ever wondered why certain data points stand out so dramatically? They might hold the key to everything from fraud detection to groundbreaking discoveries. This week on Talk Python to Me, we dive into the world of outlier detection with Python with Brett Kennedy. You'll learn how outliers can signal errors, highlight novel insights, or even reveal hidden patterns lurking in the data you thought you understood. We'll explore...
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March 14, 2025 • 79 mins
Today we explore the wild world of Python deployment with my friend, Calvin Hendryx-Parker from Six Feet Up. We’ll tackle some of the biggest challenges in taking a Python app from “it works on my machine” to production, covering inconsistent environments, conflicting dependencies, and sneaky security pitfalls. Along the way, Calvin shares how containerization with Docker and Kubernetes can both simplify and complicate deployments,...
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February 24, 2025 • 61 mins
On this episode, I'm joined by Dr. Geoff Boeing, an assistant professor at the University of Southern California whose research spans urban planning, spatial analysis, and data science. We explore why OpenStreetMap is such a powerful source of global map data—and how Geoff's Python library, OSMnx, makes that data easier to download, model, and visualize. Along the way, we talk about what shapes city streets around the world, how ur...
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February 21, 2025 • 60 mins
As Python developers, we're incredibly lucky to have over half a million packages that we can use to build our applications with over at PyPI. However, when it comes to choosing a UI framework, the options get narrowed down very quickly. Intersect those choices with the ones that work on mobile, and you have a very short list. Flutter is a UI framework for building desktop and mobile applications, and is in fact the one that we use...
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February 9, 2025 • 65 mins
In this episode, I'm joined by JJ Allaire, founder and executive chairman at Posit, and Carlos Scheidegger, a software engineer at Posit, to explore Quarto, an open-source tool revolutionizing technical publishing. We discuss how Quarto empowers users to seamlessly transform Jupyter notebooks into polished reports, dashboards, e-books, websites, and more. JJ shares his journey from creating RStudio to developing Quarto as a versati...
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January 30, 2025 • 64 mins
Join me as I chat with Rich Iannone and Michael Chow from Posit where we explore the transformative power of data tables with the Great Tables library. We'll cover practical applications of Great Tables, showcasing how thoughtful design and advanced formatting can elevate your data presentations. And you'll learn about innovative features like nano plots and interactive elements and the importance of structure, format, and style in...
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December 27, 2024 • 62 mins
Join me for an insightful conversation with Alex Monahan, who works on documentation, tutorials, and training at DuckDB Labs. We explore why DuckDB is gaining momentum among Python and data enthusiasts, from its in-process database design to its blazingly fast, columnar architecture. We also dive into indexing strategies, concurrency considerations, and the fascinating way MotherDuck (the cloud companion to DuckDB) handles large-sc...
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December 24, 2024 • 64 mins
If you're a Django developer, I'm sure you've heard so many people raving about FastAPI and Pydantic. But you really love Django and don't want to switch. Then you might want to give Django Ninja a serious look. Django Ninja is highly inspired by FastAPI, but is also deeply integrated into Django itself. We have Vitaliy Kucheryaviy the creator of Django Ninja on this show to tell us all about it.
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December 20, 2024 • 69 mins
Peter Wang has been pushing Python forward since the early days of its data science roots. We're lucky to have him back on the show. We're going to talk about the Anaconda Toolbox for Excel as well as many other trends and topics that are hot in the Python space right now. I'm sure you'll enjoy listening to the two of us exchanging our takes on the topics and trends.
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December 12, 2024 • 58 mins
LanceDB is a developer-friendly, open source database for AI. It's used by well-known companies such as Midjourney and Character.ai. We have Chang She, the CEO and cofounder of LanceDB on to give us a look at the concept of multi-modal data and how you can use LanceDB in your own Python apps.
Episode sponsors
Sentry Error Monitoring, Code TALKPYTHON
Bluehost
Talk Python Courses
Episode sponsors
Sentry Error Monitoring, Code TALKPYTHON
Bluehost
Talk Python Courses
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December 1, 2024 • 62 mins
There has been a lot of changes in the low-level Python space these days. The biggest has to be how many projects have rewritten core performance-intensive sections in Rust. Or even the wholesale adoption of Rust for newer projects such as uv and ruff. On this episode, we dive into the tools and workflow needed to build these portions of Python apps in Rust with David Seddon and Samuel Colvin.
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November 22, 2024 • 62 mins
If you are a .NET developer or work in a place that has some of those folks, wouldn't it be great to fully leverage the entirety of PyPI with it's almost 600,000 packages inside your .NET code? But how would you do this? Previous efforts have let you write Python syntax but using the full libraries (especially the C-based ones) has been out of reach, until CSnakes. This project by Anthony Shaw and Aaron Powell unlocks some pretty s...
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November 15, 2024 • 69 mins
What do developers need to know about AppSec and building secure software? We have Tanya Janca (AKA SheHacksPurple) on the show to tell us all about it. We talk about what developers should expect from threat modeling events as well as concrete tips for security your apps and services.
Episode sponsors
Posit
Bluehost
Talk Python Courses
Episode sponsors
Posit
Bluehost
Talk Python Courses
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November 5, 2024 • 57 mins
Have you heard about HTMX? We've discussed it a time or two on this show. We're back with another episode on HTMX, this time with a real-world success story and lessons learned. We have Sheena O'Connell on to tell us how she moved from a React-Django app to pure Django with HTMX.
Episode sponsors
Posit
Bluehost
Talk Python Courses
Episode sponsors
Posit
Bluehost
Talk Python Courses
Links from the show
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October 29, 2024 • 63 mins
Let's say you want to create a web app and you know Python really well. Your first thought might be Flask or Django or even FastAPI? All good choices but there is a lot to get a full web app into production. The framework we'll talk about today, Reflex, allows you to just write Python code and it turns it into a full web app running FastAPI, NextJS, React and more plus it handles the deployment for you. It's a cool idea. Let's talk...
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