Extend Podcast with Darshan Shah, MD

Extend Podcast with Darshan Shah, MD

Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results. That's why this podcast is all about cutting through the noise on how to turn back the aging clock. I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health. Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.

Episodes

April 22, 2025 87 mins

Brain fog, forgetfulness, and lack of focus are becoming the norm, but they don’t have to be. In this episode of Extend, I’m joined by Jim Kwik, a world-renowned brain coach and author of the bestselling book Limitless, to uncover how to unlock your brain’s full potential.

We dive into the science of neuroplasticity, daily habits that sabotage your memory, and how to reclaim focus in a world of constant di...

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In today’s episode of Extend, we’re tackling a crucial health issue: high blood pressure. Often called the "silent killer," high blood pressure increases your risk for heart attacks, strokes, kidney disease, and more. But what if you could prevent these risks before they escalate?

I’ll break down why measuring your blood pressure at home is far more effective than relying on a single doctor’s visit. You’ll...

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Ever feel stuck, even when you're doing all the right things? In this episode, Dr. Shah sits down with Dr. Alok Trivedi, also known as Dr. Rewire, to explore how our unresolved traumas, subconscious beliefs, and identity patterns silently shape our health, habits, and happiness.

You’ll discover how trauma wires into the nervous system, why mindset work often fails without deeper emotional integration, and ...

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With shelves full of flashy promises, it’s time to cut through the noise. In this episode, Dr. Shah and Dr. Greg Kelly explore what science actually says about supplements—and what your body truly needs to perform at its best.

 

You’ll learn how nootropics, adaptogens, and probiotics influence brain health, stress resilience, and longevity. Backed by clinical research, Dr. Kelly unpacks the key mechanisms ...

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    Inflammation drives nearly every chronic disease, yet most people overlook a key player in regulating it: the vagus nerve. This critical nerve connects brain to body, controlling digestion, heart rate, immunity, and recovery. But chronic stress shuts it down, leading to poor vagal tone, dysregulated inflammation, and reduced resilience.

    In this episode of Extend, I sit down with Dr. Navaz Habib to explore ...

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    Heart disease is still the number one cause of death, yet most people don’t realize how preventable it actually is.

    In this solo episode of Extend, I’m kicking off our new series on preventative medicine by breaking down the essential tests and metrics you need to know to protect your heart. I’ll walk you through the four key areas I evaluate in every patient—ischemia, blood pressure, electrical function, ...

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    Most people don’t think about their health until something goes wrong—but what if you could catch potential issues before they become a problem? Studies show that up to 70% of serious health conditions are preventable with early detection, yet traditional healthcare often focuses on treating symptoms rather than identifying root causes. Taking a proactive approach to your health could mean adding years to your life—and...

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    In today’s episode, I sat down with Rajeev Kapur, an AI expert and author of AI Made Simple, to explore the rapidly evolving role of AI in medicine. We dive into how AI is enhancing diagnostics, optimizing treatment plans, and helping patients take control of their own health data.

    We also break down common fears and misconceptions—will AI replace doctors? Can we trust AI-powered medical advice? How can ev...

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    Bone health is often overlooked until a fracture happens—but by then, the damage has already been done. What most people don’t realize is that bones are not just structural; they play a critical role in metabolism, hormone regulation, and long-term vitality. In fact, emerging research shows that osteoporosis and bone loss start much earlier than expected, even in people in their 30s and 40s. So how can you build and ma...

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    What if the symptoms you've been chalking up to "normal life"—brain fog, persistent insomnia, chronic fatigue, and the stubborn belly fat—were actually signs of a deeper disconnection from what makes us truly human?

    In this episode, I sit down with Jeff Krasno, author of "Good Stress: The Health Benefits of Doing Hard Things," to explore the hidden epidemic of disconnection and its profound impact on our h...

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    We often hear about the latest treatments for chronic disease, but what if you could prevent these conditions before they even begin? The truth is, most of the top 10 causes of death are entirely preventable, yet our healthcare system focuses on treating disease rather than stopping it in its tracks.

    In today’s episode of Extend, I’m breaking down the science of preventative medicine, and how you can take ...

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    Fasting has been praised as a powerful tool for weight loss, metabolic health, and longevity, but is it always beneficial? The truth is, fasting can either optimize your biology or work against you, depending on how, when, and for how long you do it. Research now suggests that skipping breakfast, a common intermittent fasting practice, is linked to higher cardiovascular risk and increased mortality. At the same time, s...

    What if the symptoms you’ve been chalking up to aging, low energy, brain fog, stubborn belly fat, and lack of motivation, were actually signs of a deeper hormonal imbalance? 

    The truth is, testosterone levels in men have been plummeting for decades, and it’s not just about aging. Environmental toxins, chronic stress, poor sleep, and nutrient deficiencies are creating a perfect storm for hormonal disruption...

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    Have you ever wondered why gut health is at the root of everything, from metabolism and cravings to immunity and even mental clarity?

    Why do some people struggle with weight gain, energy crashes, and digestive issues despite eating well? And could the rise of GLP-1 medications like Ozempic be a sign that we’ve been ignoring a natural solution all along?

    In today’s episode of Extend, I’m joined...

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    What if everything you’ve been told about nutrition is only half the story? It’s not just about avoiding carbs, counting macros, or following the latest health trend—it’s about how food impacts your metabolism, gut, and long-term health on a deeper level. The problem? Most people are stuck in a cycle of restrictive diets, misinformation, and ultra-processed foods that silently sabotage their well-being.

    In...

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    Sleep isn't just about rest, it's a critical pillar of metabolic health, cognitive function, and longevity. In this solo episode of Extend, I dive deep into the science of sleep routines and circadian rhythms. I share how proper sleep habits are foundational to the new healthcare paradigm focused on vitality rather than disease management.

    I explain that your sleep routine actually begins the moment you wa...

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    Have you ever felt like mental health care is stuck in the past?

    Why are rates of depression, anxiety, and even conditions like autism skyrocketing in today’s world? And why does traditional treatment often fall short? Spoiler: the answer lies deeper than just brain chemistry… it’s all about your metabolic health.

    In this week’s episode of Extend, I’m joined by Dr. Chris Palmer, a psychiatrist...

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    What if the key to peak performance and longevity isn’t just in your workouts, diet, or sleep, but in how well your body handles stress? Optimizing your health isn’t just about the latest supplements or fitness trends, it’s about understanding your nervous system, heart rate variability (HRV), and how small daily habits shape your resilience over time. Most people try to eliminate stress, but the real goal is building ...

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    If you’re struggling to fall asleep, waking up in the middle of the night, or feeling groggy in the morning, the problem might not be you—it might be your sleep environment. Most people don’t realize just how much their bedroom setup impacts sleep quality. In this episode of Xtend, I’m breaking down exactly how you can optimize your space to promote deep, restor...

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    Do you ever feel like your wellness journey is missing something? We often focus on physical health—what we eat, how we exercise—but overlook the powerful role our mind plays in driving true transformation. From reducing stress to optimizing focus, your thoughts and beliefs shape every aspect of your well-being. 

    The key to lasting change may be closer than you think: it starts in your mind…

    W...

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