Proteomics in Proximity
Proteomics in Proximity discusses the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. Co-hosted by Olink's Dale Yuzuki, Cindy Lawley and Sarantis Chlamydas.
Episodes
Welcome to the Olink® Proteomics in Proximity podcast!
Below are some useful resources mentioned in this episode:
Olink® Reveal, accessible NGS-based proteomics for every lab: https://olink.com/products/olink-reveal
Olink tools and software
· Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/
Welcome to the Olink® Proteomics in Proximity podcast!
Below are some useful resources mentioned in this episode:
Olink tools and software
· Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/
· Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simulta...
Welcome to the Olink® Proteomics in Proximity podcast!
Below are some useful resources mentioned in this episode:
Olink tools and software
Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/
Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streaml...
Welcome to the Olink® Proteomics in Proximity podcast!
Below are some useful resources mentioned in this episode:
UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies
UKB-PPP online resources developed by Nick Lehner ...
Welcome to the Olink® Proteomics in Proximity podcast!
Below are some useful resources mentioned in this episode:
Olink tools and software
• Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/
• Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously wit...
Welcome to the Olink® Proteomics in Proximity podcast!
Below are some useful resources from this episode:
Published study of primary focus
Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C. Proteogenomic links to human metabolic diseases. Nat Metab. 2023 Mar;5(3):516-528. doi: 10.1038/s42255-023-00753-7. Epub 2023 Feb 23. Erratum in: Nat Metab. 2023 Mar 19;: PM...
Welcome to the Olink® Proteomics in Proximity podcast!
Below are some useful resources from this episode:
Published study of primary focus
Álvez MB, Edfors F, von Feilitzen K, Zwahlen M, Mardinoglu A, Edqvist PH, Sjöblom T, Lundin E, Rameika N, Enblad G, Lindman H, Höglund M, Hesselager G, Stålberg K, Enblad M, Simonson OE, Häggman M, Axelsson T, Åberg M, Nordlund J, Zhong W, Karlsson M, Gyllensten U, Ponten F, Fagerb...
Welcome to Olink Proteomics in Proximity Podcast!
Below are some useful resources from this episode:
Highlighted publication:
Girerd N, et al. Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study. Circ Heart Fail. 2023 May;16(5):e009694. doi: 10.1161/CIRCHEARTFAILURE.122.009694 https://pubmed.nc...
Welcome to Olink Proteomics in Proximity Podcast!
Below are some useful resources from this episode:
Highlighted article from the UK Biobank Pharma Proteomics Project (UKB-PPP): Styrkarsdottir U, Lund SH, Thorleifsson G, Saevarsdottir S, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K. Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Pro...
Welcome to Olink Proteomics in Proximity Podcast!
Below are some useful resources from this episode:
Highlighted pre-print article: Malarstig A, Grassman F, Dahl L, et al. Evaluation of Circulating Plasma Proteins in Breast Cancer: A Mendelian Randomization Analysis. ResearchSquare 2023.04.04. DOI: https://doi.org/10.21203/rs.3.rs-2749047/v1
Highlighted platform that was used to measure proteins in this study wit...
Welcome to Olink Proteomics in Proximity Podcast!
Below are some useful resources from this episode:
Highlighted publication: Grasberger H, Magis AT, Sheng E, Conomos MP, Zhang M, Garzotto LS, Hou G, Bishu S, Nagao-Kitamoto H, El-Zaatari M, Kitamoto S, Kamada N, Stidham RW, Akiba Y, Kaunitz J, Haberman Y, Kugathasan S, Denson LA, Omenn GS, Kao JY. DUOX2 variants associate with preclinical disturbances in microbiota-immune ...
Welcome to Olink Proteomics in Proximity Podcast!
Below are some useful resources from this episode:
Highlighted publication: Diaz-Canestro C, Chen J, Liu Y, Han H, Wang Y, Honoré E, Lee CH, Lam KSL, Tse MA, Xu A. A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes. Cell Rep Med. 2023 Feb 21;4(2):100944. doi: 10.1016/j.xcrm.2023....
Highlighted publication: Zannad F, Ferreira JP, Butler J, Filippatos G, Januzzi JL, Sumin M, Zwick M, Saadati M, Pocock SJ, Sattar N, Anker SD, Packer M. Effect of empagliflozin on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme. Eur Heart J. (2022) 43(48):4991-5002. doi:10.1093/eurheartj/ehac495. PMID: 36017745; PMCID: PMC9769969.
All about Olink Flex: https://olink.com/flex
Olink Insight (where you can build a 21-plex Olink Flex panel from 200 proteins): https://insight.olink.com
Sweden’s Science for Life laboratory website: https://www.scilifelab.se/about-us/
In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink Proteomics assay technology called the Proximity Extension Assay (PEA), and more inf...
Primary reference:
Loriot Y and Italiano A et al. Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker of immune-checkpoint blockade resistance. Ann Oncol. (2021) 32(11):1381-1390. doi:10.1016/j.annonc.2021.08.1748
Olink Insight Knowledge Platform with Hilda Andersson, Episode 6, Proteomics in Proximity.
Description of the MATCH-R clinical trial, “A Prospective Trial to Study...
Primary reference:
Ticau S and Nioi P et al. (2021) Neurofilament Light Chain as a Biomarker of Hereditary Transthyretin-Mediated Amyloidosis. Neurology. 96(3):e412-e422. doi:10.1212/WNL.0000000000011090
Information about the APOLLO clinical trial: “APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis” Link to NCT01960348 at the US National Librar...
The 2019 Cell Reports paper, “Chromatin Remodeling in Response to BRCA2-Crisis” by J Gruber and M Snyder et al. is available online here.
Dr. Michael Snyder’s Stanford laboratory home page is here.
A 1998 Oncogene paper, “The BRCA2 is a histone acetyltransferase” by S Habibur and E S P Reddy et al. is located online here. A 2014 Cancer Discovery paper, “R-loop Processing by BRCA2 is Required for Genomic Stability” is located...
Primary reference: Suhre K, Sarwath H, Engelke R, Sohail MU, Cho SJ, Whalen W, Alvarez-Mulett S, Krumsiek J, Choi AMK, Schmidt F. Identification of Robust Protein Associations With COVID-19 Disease Based on Five Clinical Studies. Front Immunol. 2022 12:781100. doi:10.3389/fimmu.2021.781100
Dr. Karsten Suhre’s Weill Cornell Medicine laboratory page: https://vivo.weill.cornell.edu/display/cwid-kas2049
Leukemia ...
To access Olink Insight free of charge, visit https://insight.olink.com
The first two data stories, with Normal Range data and COVID-19 data, has been recently updated with the first Disease Atlas, with data characterizing 15 cancer types. This is available on Olink Insight here: https://insight.olink.com/data-stories/disease-atlas-cancer
To access the COVID-19 Data Story dataset itself, information about the study ...
List of names and affiliations mentioned in the UK Biobank context: Mark McCarthy (Genentech), Slavé Petrovski (AstraZeneca), Chris Whelan (Johnson and Johnson), Erin Smith (Takeda Pharmaceuticals), Melissa Miller (Pfizer), Ben Sun (Biogen).
The ASHG announcement, honoring Sir Peter Donnelly, CEO of Genomics plc and Emeritus Professor of Statistical Science at the University of Oxford with the William Allan Award.
Popular Podcasts
The World's Most Dangerous Morning Show, The Breakfast Club, With DJ Envy And Charlamagne Tha God!
Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations. Follow now to get the latest episodes of Dateline NBC completely free, or subscribe to Dateline Premium for ad-free listening and exclusive bonus content: DatelinePremium.com
Welcome to "Decisions, Decisions," the podcast where boundaries are pushed, and conversations get candid! Join your favorite hosts, Mandii B and WeezyWTF, as they dive deep into the world of non-traditional relationships and explore the often-taboo topics surrounding dating, sex, and love. Every Monday, Mandii and Weezy invite you to unlearn the outdated narratives dictated by traditional patriarchal norms. With a blend of humor, vulnerability, and authenticity, they share their personal journeys navigating their 30s, tackling the complexities of modern relationships, and engaging in thought-provoking discussions that challenge societal expectations. From groundbreaking interviews with diverse guests to relatable stories that resonate with your experiences, "Decisions, Decisions" is your go-to source for open dialogue about what it truly means to love and connect in today's world. Get ready to reshape your understanding of relationships and embrace the freedom of authentic connections—tune in and join the conversation!
Ding dong! Join your culture consultants, Matt Rogers and Bowen Yang, on an unforgettable journey into the beating heart of CULTURE. Alongside sizzling special guests, they GET INTO the hottest pop-culture moments of the day and the formative cultural experiences that turned them into Culturistas. Produced by the Big Money Players Network and iHeartRadio.
ALL THE SMOKE pairs two of the most outspoken and controversial players of their time. Known as fiery, intense competitors during their on-court careers, Matt Barnes and Stephen Jackson are now two of the most widely respected voices by today’s crop of NBA stars. Serving as mentors to numerous players throughout the league and with their hands firmly on the pulse of the game, they have first-hand insight into the minds, lives and pressing issues facing today’s players. Barnes and Jackson, who have played alongside two generations of All-Stars, will dish on the latest news and drama from on and off the court without boundaries.