The Orange Pill Podcast

The FDA has finalized its guidance on identity and safety information for New Dietary Ingredient Notifications (NDINs). But what does this mean for the dietary supplement industry?

In Episode 149 of The Orange Pill Podcast, we break down the finalized guidance, exploring the FDA's recommendations for establishing ingredient identity, presenting safety evidence, and supporting safety conclusions.

With KGK Science's regulatory expert...

What if slowing biological aging didn't require expensive treatments or extreme lifestyle changes?

In Episode 148 of The Orange Pill Podcast, we explore findings from the landmark DO-HEALTH Bio-Age trial, which followed 777 adults aged 70 and older over three years to investigate whether omega-3 fatty acids, vitamin D, and simple home exercise could influence biological aging.

Using advanced epigenetic clocks, researchers found tha...

Creatine is best known for building muscle and boosting athletic performance, but could its benefits extend beyond the gym?

In this episode of The Orange Pill Podcast, we explore a 2025 study published in Nutrients examining creatine's effects on sleep, cognitive function, physical performance, and muscle recovery. After just seven days of supplementation, participants reported better sleep quality, demonstrated improved attention,...

What if your muscles could regain strength before the soreness disappears?

Emerging research suggests that plant-derived polyphenols may influence exercise recovery in ways that go beyond simply reducing discomfort. Recent studies investigating Sorghum bicolor and specialized fruit polyphenol extracts have reported promising findings involving muscle strength recovery, exercise-related biomarkers and cellular signaling pathways as...

When it comes to supplements, we often assume that a higher dose means a bigger effect. A 2025 randomized, double-blind crossover trial of Rhodiola rosea challenges that assumption.

After just seven days, 200 mg/day outperformed a 1,500 mg/day dose across several resistance-training outcomes, including repetition volume and upper-body strength, while neither dose meaningfully improved 30-second cycling sprint performance. 

In ...

Ashwagandha has become synonymous with stress relief, but what happens when you put that claim through a placebo-controlled clinical trial?

A 12-week randomized, double-blind study of a standardized ashwagandha root extract found an unexpected result: perceived stress improved substantially in both the ashwagandha and placebo groups, with no significant difference between them. But look beyond stress scores, and a much more interes...

Can the same supplement produce completely opposite biological effects depending on sex?

A 2026 preclinical study investigating calcium alpha-ketoglutarate (Ca-αKG) in mouse models of lung adenocarcinoma found a striking divergence: supplementation reduced tumor growth and cell proliferation in female mice, while increasing both in males. 

In Episode 143 of the Orange Pill Podcast, we explore how researchers traced this unexpe...

Dietary supplements are no longer a niche wellness habit. According to a new 2026 report from the National Center for Health Statistics, 60.2% of U.S. adults used at least one dietary supplement in the previous 30 days, and 38.7% used two or more.

In Episode 142 of the Orange Pill Podcast, we unpack the latest NHANES data to explore who's supplementing, how habits change with age and sex, ...

IBS isn't simply a digestive disorder, it's increasingly understood as a complex disorder of gut-brain interaction.

An 8-week randomized, double-blind, placebo-controlled trial investigated whether a multi-species probiotic could influence not only IBS-related quality of life, but also oxidative stress and inflammatory biomarkers.

In Episode 141 of the Orange Pill Podcast, we unpack four s...

GLP-1 receptor agonists have transformed the conversation around obesity and metabolic health. But as their use continues to grow, researchers and clinicians are beginning to pay closer attention to the nutritional consequences that can accompany significant appetite suppression, rapid weight loss, and persistent gastrointestinal side effects.

In this episode of The Orange Pill Podcast, we...

Fiber isn't just about digestive health.

A systematic review and meta-analysis of 27 randomized controlled trials involving more than 1,400 participants found that soluble fiber supplementation was associated with improvements in body weight, BMI, waist circumference and markers of insulin resistance.

In Episode 139 of the Orange Pill Podcast, we explore why 12 weeks matters, how soluble f...

Creatine may be famous for building muscle but its next frontier could be the brain.

A 2024 systematic review and meta-analysis of 16 randomized controlled trials found that creatine supplementation was associated with improvements in memory, with additional promising findings around attention and processing speed.

In Episode 138 of the Orange Pill Podcast, we explore how creatine helps fu...

What if the hardening of our arteries isn't entirely inevitable?

A two-year study investigated whether vitamin K2 as MK-7 could influence the progression of coronary artery calcification in patients with symptomatic coronary artery disease. While calcification progressed in both groups, participants receiving 360 μg of MK-7 daily showed significantly slower progression compared with placeb...

A 2025 randomized, double-blind, placebo-controlled trial explored whether a combination of Polypodium leucotomos, Red Orange extract, and vitamins could help strengthen the skin’s natural defenses against UVB exposure.

After eight weeks, participants showed a 23.8% increase in UV tolerance and a 46.2% reduction in UVB-induced redness, without significantly affecting tanning.

In Episode 136 of the Orange Pill Podcast, we expl...

What does it really cost to make GRAS notification mandatory?

The FDA’s proposed GRAS overhaul promises greater transparency, but the headline numbers may not tell the whole story. Beyond the administrative cost of filing a notification are potentially much larger expenses tied to toxicology, exposure assessments, expert review, regulatory support, and delays.

In Episode 135 of the O...

What if one of the world’s oldest, and most expensive spices could have a measurable impact on the everyday “gray zone” of mental health?

In Episode 134 of the Orange Pill Podcast, we explore a 2025 randomized controlled trial examining a standardized saffron extract in 202 adults experiencing subclinical depressive symptoms.

We break down five findings from the study and...

Millions of people struggle with constipation, yet many still rely on laxatives that simply force the digestive system into action.

In Episode 132 of the Orange Pill Podcast, we explore why fructooligosaccharides (FOS), a clinically studied prebiotic, may represent a smarter approach to digestive health.

Learn how FOS nourishes beneficial gut bacteria, promotes natural bowel function, and ...

Clinical trials are essential, but choosing the wrong dose, population, or endpoint can derail a study before it begins.

In Episode 131 of the Orange Pill Podcast, we introduce the KGK Design Intelligence Lab and explore how in silico dietary modeling can simulate health outcomes across virtual populations before the first participant is enrolled.

By combining randomized clinical tr...