The Sepsis Spectrum

The Sepsis Spectrum

Forget everything you ever read in a textbook when it comes to antimicrobial resistance (AMR) and sepsis complications – because they rarely play by the rules. They evolve, adapt, and strike before it’s too late. While classic symptoms like fever, tachycardia, and hypotension are well known, the real challenge lies in recognizing the unexpected to reduce your mental list of those unknown, unknowns. Hosted by Critical Care RN & CNS Author Nicole Kupchik, The Sepsis Spectrum is an exploration of real-world patient cases, expert insights, and clinical deep dives to unravel the most complex presentations facing modern medicine. Through gripping stories and in-depth interviews, Nicole examines diagnostic challenges, cutting-edge treatments, and the growing threat of AMR. Designed for healthcare professionals at every level, The Sepsis Spectrum is about leaving you with more than compelling stories—it’s a vital resource in podcast form. Whether you’re at the bedside or in the classroom, you’ll finish each episode with practical, life-saving knowledge—and earn free CE Contact Hours for Nurses along the way. The fight against sepsis and AMR starts with recognition — because the most dangerous threats are the ones you don’t see coming. A Sepsis Alliance Podcast Nursing CE Contact Hours Available - Sepsis Alliance is a provider approved by the California Board of Registered Nursing, Provider Number CEP17068. Most U.S. states accept CE provided through the California Board of Registered Nursing, but nurses in other states should check with their local and state accrediting bodies to confirm. Canadian and non-US based nurses should consult their provincial or territorial regulator to confirm acceptance.

Episodes

July 15, 2025 52 mins
Hospital-onset sepsis presents a complex and urgent challenge at the intersection of healthcare-associated infections (HAIs), antimicrobial resistance (AMR), and clinical decision-making. Nicole welcomes Dr. Jennifer Ginestra and Dr. Emi Minejima to examine how HAIs contribute to both AMR and the development of sepsis within hospital settings—and why these cases often carry higher risks and worse outcomes. Together they'll explore ...
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Can pre-hospital teams catch sepsis before the hospital even sees it coming? Nicole sits down with EMS thought leader Eric Bauer to break down how tools like capnography, lactate testing, and passive leg raise are transforming early sepsis care. They dig into why respiratory rate matters more than we think, what end-tidal CO₂ can really tell us, and why protocols don’t have to mean tunnel vision. It’s a smart, field-tested look at ...
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July 1, 2025 39 mins
Can standard sepsis protocols catch what the gut already knows? In this conversation, Nicole sits down with Dr. Laura Kahn to explore how the microbiome could transform our understanding of sepsis, antimicrobial resistance, and upstream prevention. They dive into One Health thinking, gut-brain signaling, dysbiosis as an early disease marker, and why your patient’s toilet might someday replace lab work. A provocative look at the lim...
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July 1, 2025 38 mins
Unpack the critical links between infection, antimicrobial resistance, and sepsis with host Nicole Kupchik, and learn how together, they’re placing intense strain on public health systems, communities, and the broader social factors that shape health and well-being. Joined by sepsis and infection prevention leaders Pat Posa and Dr. Cindy Hou, this episode explores how preventing infections before they happen remains one of the most...
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April 29, 2025 1 min
~ SERIES PREMIERES JUNE 17, 2025 ~ If a microbial mutation falls in a bloodstream forest… does it make a sound? When she’s not pondering weird stuff like that, Nicole Kupchik (Critical Care RN, CNS) is busy investigating the weird, wide world of sepsis and antimicrobial resistance. Through shocking real-world cases that don’t quite follow the textbook — and eye-opening conversations with expert guests — she’s getting to th...
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