Knockout Nerds

Knockout Nerds

Setoiyo loves sports. Darryl doesn’t. Darryl’s a nerd. Setoiyo isn’t. Comedians Darryl Charles and Setoiyo clash and connect as they school each other on their wildly different worlds—and try to make sense of everything else in between. Smart, silly, and always surprising—jump in on the convo!

Episodes

March 23, 2026 36 mins

Darryl is at the helm this week with a nostalgic deep dive into the mighty video game cartridge. From its founder, through its surprising evolution, to why Nintendo just can’t quit it. It’s a full retrospective on the storage format that defined childhoods and refuses to die.

Along the way, we get hot takes on raising your sons right and meet the newest villain in Darryl’s personal lore: his archnemesis.

It’s gaming history, parentin...

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Setoiyo helms this episode with a breakdown of "Sugar" Ray Leonard and Thomas "Motor City Cobra" "The Hitman" Hearns. Watch Darryl learn all about this legendary boxing match, with hot takes about driving and what it's like to be a Drake fan. This episode is the pound for pound best!

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Darryl's at the helm this week; informing Setoiyo about the Fallout franchise. Learn about the alternate history that has grown from RPG to Prime and Beyond! Plus hot takes about looksmaxxing and being an admin to the Legion of Doom. Long Live Sheiky, Baby!


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March 2, 2026 38 mins

Setoiyo returns to the helm with a deep dive into the origins and impact of the “Great White Hope,” tracing how the term started in boxing and why Gerry Cooney’s story still hits with so much weight. It’s part cultural unpacking, part tribute, and fully Knockout Nerds energy.

Plus we've got some HOT takes on what makes someone the perfect friend and how to show your man you believe in him. It’s history, humor, and heart in one r...

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February 23, 2026 33 mins

Darryl’s steering the ship this week with a deep dive into the wild, yeasty world of alcohol. Whether it’s beer, wine, or the hard stuff, it all starts with microscopic magic.

Setoiyo’s along for the ride with hot takes on what it really means to be an eater, while Darryl tries to convince the world to be good for goodness’ sake (a big ask, but he’s trying).

It’s science, silliness, fermentation, and philosophy, served with a wink.

Fo...

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February 16, 2026 33 mins

Setoiyo is at the helm this week with the story of the fight trilogy between Sugar Ray Leonard and The Hands of Stone Roberto Durán. We round out the episode with hot takes on googling everything and Pugh FTW!

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February 9, 2026 26 mins

Darryl is running things this week with Setoiyo's introduction to speedrunning. Learn all about this subsection of gaming that is far more popular and far better for the world than you think it is. Plus we've got hot takes on AI and the comment section.

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Email us! knockoutnerds@gmail.com



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January 31, 2026 28 mins

The Knockout Nerds are officially on video, where Setoiyo walks us through the iconic 1966 championship bout between Muhammad Ali and Cleveland “Big Cat” Williams, a masterclass in footwork, finesse, and pure Ali disrespect. Darryl jumps in with hot takes on the incoming auntie‑music revolution (brace yourself), plus some unexpectedly poignant parenting wisdom to round things out. We’re thrilled to be recording from Anga Studios an...

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January 24, 2026 25 mins

The Knockout Nerds are back with a nerdy dive into the world of e-cigarettes. Darryl has researched everything you need to know about those fat clouds, how they're different from your standard cowboy killers, and what you need to look out for on your next rip. Setoiyo also has strong feelings. Plus hot takes on high-value 50/50 alpha entertainment and what a comedy career really needs. Smoke 'em if you got 'em, this epi...

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January 17, 2026 38 mins

The Knockout nerds are back! After touching some snow covered grass, Setoiyo is back at the helm to break down the 2025 clash between Anthony Joshua's dazzling career and Jake Paul's very different trajectory out of Cleveland. Darryl and Setoiyo also give you some hot takes on who really has good genes, pro-social gym behavior and the finer art of mens grooming.


Perfect for fans of boxing, MMA, and podcasts that don'...

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November 15, 2025 28 mins

Darryl’s in the driver’s seat this week, sliding into the slick, strange saga of Teflon. From miracle coating to chemical panic: it’s non-stick science meets existential dread. Setoiyo’s along for the ride, questioning everything from cookware safety to cardio logic. We're also serving a side of hot takes on hiking culture and political hope in the wake of the latest Blue Wave.It’s chemistry, commentary, and chaos, wrapped in a...

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November 2, 2025 49 mins

Setoiyo is taking the lead this week to tell us about Mike Tyson's first defeat, refereed by none other that Barbara Walters . Darryl is here to shout out Brownsville and make peace with his ever-growing list of enemies. Glove up and join the conversation!

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October 25, 2025 36 mins

Darryl's leading a Nerd week with his top 3 innovations brought to you by Big War, plus a few honorable military mentions certain to make you giggle. Setoiyo is also coming through with some industrial hot takes on a weirdly popular new kink. We've made sure its never too complex to listen along and join in on the fun. Like, share, subscribe and see what we did there!

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Setoiyo takes us on an important trip to Britain in 1963 to remember the time that a young Cassius Clay almost ruined the career of Muhammad Ali. Darryl has thoughts on the edge, and you must leave the anti-Nickelback cult. Days without mentioning bidets:1

Here's a lovely picture show of the first fight, as promised.


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October 13, 2025 45 mins

Darryl is heading this episode, dragging Setoiyo into a fun discussion on Copaganda and critical media consumption. With more thoughts on America's unwelcome saints: new and old. Plus unwelcome club attention leads to more bidet talk. It's a super sized episode, dig in! *L&O gavel sounds*

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Our recap on UFC 320, Live from Las Vegas! The fights were in Las Vegas, not us.

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September 30, 2025 16 mins

An all hot take special edition of the Knockout Nerds has Setoiyo and Darryl giving their impressions of The Riyadh Comedy Festival. Think pieces will be written, comedians will be paid, and audiences will be entertained. The question is: Are you not? Also, more bidet talk. Shoutout to Charmin! Serious promotional inquiries can be directed to our email or Instagram, as always!

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September 27, 2025 36 mins

Lively convo this episode about the way CTE and racism combine to form the Captain Planet that is UFC fighter Bryce Mitchell. Setoiyo takes Darryl on a journey through his hits, which include all the hallmarks of that uncle you won't talk to or about. Plus inspired analysis on many aspects of cheeks and defense of cinnamon. Take the power back with us!

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Email us! knockoutnerds@gmail.com

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September 20, 2025 30 mins

Darryl’s fully charged and ready to spark some chaos in this electrifying episode of Knockout Nerds. From lithium-ion meltdowns to why your scooter might be plotting arson, we’re breaking down the battery basics and the fiery consequences of tech at capitalistic capacity.

Setoiyo’s riding shotgun with spicy takes on guacamole culture. Plus fitness! It’s volts, vibes, and very questionable science.

We’re energized. We’re overheating. ...

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September 13, 2025 43 mins

Setoiyo is throwing haymakers at Darryl in this episode of Knockout Nerds with the story of George Foreman's rise, fall, and unwarranted beating of 5 men in a single night. Find out what happens when men are embarrased before they can get to therapy or The Church. Plus some hot takes on how to deal with the conservatives in your life. Spoiler alert: it isn't beating 5 of them in a row, or debating 20. #ForemanVsFive #George...

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