Out of This World — The Podcast

Out of This World — The Podcast

Psychedelic-medicine intelligence in plain language — one show, two strands. ORACLE: the daily signal, narrated, plus a two-host deep dive on what today means for the field. JOURNAL: warm narrations of OOTW evidence-review articles, plus two-host deep dives on the science. — THE OUT OF THIS WORLD ECOSYSTEM — - OOTW Mission Control — the brand home for our nine wellness initiatives: https://ootw.co - OOTW Cacao — functional-mushroom cacao & our daily content engine: https://outofthisworldcacao.com - OOTW Journal — 50 long-form articles, each with audio, podcast & video deep-dives: https://ootwjournal.com - OOTW Oracle — a daily AI-swarm engine publishing predictions on psychedelic medicine: https://ootworacle.com - OOTW Spirit Guide — an AI subscription companion for the psilocybin journey: https://ootwspiritguide.com - OOTW Veterans — a Veterans Restoration Initiative offering psychedelic healing pathways: https://ootwveterans.com - OOTW Ritual — Moon Rituals for navigating the lunar cycle and intention-setting: https://ootwritual.com - OOTW Clarity — the Awareness Quiz — explore your readiness for intentional expansion: https://ootwclarity.com — FOLLOW OOTW — - Instagram: https://instagram.com/ootwchocolate - X / Twitter: https://x.com/ootwchocolate - TikTok: https://www.tiktok.com/@magicalmushroomworld - LinkedIn: https://www.linkedin.com/in/out-of-this-world-oracle/ - Substack: https://substack.com/@ootwstoryteller - Telegram: https://t.me/+_ujuFfAB8TRiNGVh [OOTW-ECOSYSTEM-LINKS]

Episodes

July 30, 2026 53 mins
A two-host deep dive on psychedelics and the brain - new connections versus new cells, the month-long dendritic spines, the honest limits of the evidence, and the window of heightened learning. Education, not medical advice. Read the article: https://ootwjournal.com/article-108-psychedelics-neurogenesis
Listen
Watch
Mark as Played
The full deep dive, narrated - do psychedelics grow new brain cells? Mostly no, and the distinction matters. Covers neurogenesis versus neuroplasticity, the landmark Ly 2018 and Shao 2021 studies (spines that lasted a month), the 5-HT2A-BDNF-TrkB-mTOR mechanism, the weaker new-neuron evidence, the null human BDNF data, and the critical-period-reopening idea. Education, not medical advice. Read the article: https://ootwjournal.com/...
Listen
Watch
Mark as Played
A two-host deep dive on 5-MeO-DMT - total ego dissolution, the 5-HT1A mechanism, the neuroscience of the void, the new depression trials, and the honest danger. Education, not medical advice. Read the article: https://ootwjournal.com/article-107-5meo-dmt-ego-dissolution
Listen
Watch
Mark as Played
The full deep dive, narrated - how 5-MeO-DMT, 'the God molecule' from the Sonoran Desert toad, produces the most complete and reliable ego dissolution of any known psychedelic. Covers the 5-HT1A doorway that sets it apart from classic psychedelics, the oceanic-boundlessness phenomenology, the default-mode-network collapse, the fast-moving GH001 and BPL-003 depression trials, and the serious risks - serotonin toxicity, potency, and ...
Listen
Watch
Mark as Played
A two-host deep dive on LSD microdosing - the placebo problem, what a sliver of LSD really does, the felt-versus-measured gap, the safety question, and the honest bottom line. Education, not medical advice. Read the article: https://ootwjournal.com/article-106-lsd-microdosing-science
Listen
Watch
Mark as Played
The full deep dive, narrated - the honest evidence on LSD microdosing. Ask a microdoser and it works; ask a controlled trial and it mostly shrugs. Covers the placebo problem and the landmark self-blinding study, the real-but-modest pharmacology of low-dose LSD, the gap between felt and measured effects, the theoretical long-term cardiac risk, and why it is not the same as the full-dose LSD therapy in the news. Education, not medica...
Listen
Watch
Mark as Played
July 30, 2026 47 mins
A two-host deep dive on the 5-HT2A receptor - the necessity proof, the excitation, the plasticity revolution, and how one receptor became the gateway to altering consciousness. Education, not medical advice. Read the article: https://ootwjournal.com/article-105-serotonin-2a-receptor
Listen
Watch
Mark as Played
July 30, 2026 12 mins
The full deep dive, narrated - why the serotonin 2A receptor is the master switch of every classic psychedelic. LSD, psilocybin, DMT and mescaline all converge on it, and blocking it with ketanserin abolishes the trip. Covers cortical excitation, the intracellular-receptor discovery, structural neuroplasticity via BDNF-TrkB-mTOR, the cryo-EM structures, non-hallucinogenic psychoplastogens, and the honest open questions. Education, ...
Listen
Watch
Mark as Played
Today's OOTW Oracle signal, narrated — “The Waiting Room Speaks.” What today means for the field in plain language, plus the day's confidence-scored calls.
Listen
Watch
Mark as Played
A two-host deep dive into today's Oracle signal “The Waiting Room Speaks” — the story behind the numbers, in plain English.
Listen
Watch
Mark as Played
Today's OOTW Oracle signal, narrated — “The Argument Over Proof.” What today means for the field in plain language, plus the day's confidence-scored calls.
Listen
Watch
Mark as Played
A two-host deep dive into today's Oracle signal “The Argument Over Proof” — the story behind the numbers, in plain English.
Listen
Watch
Mark as Played
A two-host deep dive on ibogaine - the addiction interruption, the GDNF and nicotinic reset of reward circuitry, the dream-like life-review, the new trials, and the honest, serious cardiac risk. Education, not medical advice. Read the article: https://ootwjournal.com/article-104-ibogaine-addiction-interruption
Listen
Watch
Mark as Played
The full deep dive, narrated - how ibogaine, from the West African iboga root, can switch off opioid withdrawal and cravings in a single session. A multi-target molecule (NMDA, opioid, sigma, alpha3beta4 nicotinic, serotonin) that appears to reset reward circuitry through GDNF, wrapped in a long visionary life-review. Covers the Bwiti origins, the mechanism, the 2024-2025 Stanford and Texas trials, and the serious cardiac danger. E...
Listen
Watch
Mark as Played
A two-host deep dive on ketamine and depression - the NMDA paradox, the glutamate surge, the rapid synaptic rebuild, the speed revolution, and the honest clinical picture. Education, not medical advice. Read the article: https://ootwjournal.com/article-103-ketamine-nmda-receptor
Listen
Watch
Mark as Played
The full deep dive, narrated - how ketamine blocks the NMDA glutamate receptor and, paradoxically, lifts depression in hours. By silencing NMDA on inhibitory interneurons it triggers a glutamate surge that switches on AMPA, BDNF and mTOR, driving rapid regrowth of synapses. Covers the disinhibition paradox, synaptogenesis, dissociation, the HNK metabolite, esketamine's 2025 monotherapy approval, and the honest risks. Education, not...
Listen
Watch
Mark as Played
Today's OOTW Oracle signal, narrated — “The Quiet Bench.” What today means for the field in plain language, plus the day's confidence-scored calls.
Listen
Watch
Mark as Played
A two-host deep dive into today's Oracle signal “The Quiet Bench” — the story behind the numbers, in plain English.
Listen
Watch
Mark as Played
Today's OOTW Oracle signal, narrated — “The Giant's Money Speaks.” What today means for the field in plain language, plus the day's confidence-scored calls.
Listen
Watch
Mark as Played
A two-host deep dive into today's Oracle signal “The Giant's Money Speaks” — the story behind the numbers, in plain English.
Listen
Watch
Mark as Played

Popular Podcasts

    Current and classic episodes, featuring compelling true-crime mysteries, powerful documentaries and in-depth investigations. Follow now to get the latest episodes of Dateline NBC completely free, or subscribe to Dateline Premium for ad-free listening and exclusive bonus content: DatelinePremium.com

    Hey Jonas!

    Hey Jonas! The official Jonas Brothers podcast. Hosted by Kevin, Joe, and Nick Jonas. It’s the Jonas Brothers you know... musicians, actors, and well, yes, brothers. Now, they’re sharing another side of themselves in the playful, intimate, and irreverent way only they can. Spend time with the Jonas Brothers here and stay a little bit longer for deep conversations like never before.

    Betrayal Weekly

    Betrayal Weekly is back for a new season. Every Thursday, Betrayal Weekly shares first-hand accounts of broken trust, shocking deceptions, and the trail of destruction they leave behind. Hosted by Andrea Gunning, this weekly ongoing series digs into real-life stories of betrayal and the aftermath. From stories of double lives to dark discoveries, these are cautionary tales and accounts of resilience against all odds. From the producers of the critically acclaimed Betrayal series, Betrayal Weekly drops new episodes every Thursday. If you would like to share your story, you can reach out to the Betrayal Team by emailing them at betrayalpod@gmail.com and follow us on Instagram at @betrayalpod and @glasspodcasts. Please join our Substack for additional exclusive content, curated book recommendations, and community discussions. Sign up FREE by clicking this link Beyond Betrayal Substack. Join our community dedicated to truth, resilience, and healing. Your voice matters! Be a part of our Betrayal journey on Substack.

    Stuff You Should Know

    If you've ever wanted to know about champagne, satanism, the Stonewall Uprising, chaos theory, LSD, El Nino, true crime and Rosa Parks, then look no further. Josh and Chuck have you covered.

    Crime Junkie

    Does hearing about a true crime case always leave you scouring the internet for the truth behind the story? Dive into your next mystery with Crime Junkie. Every Monday, join your host Ashley Flowers as she unravels all the details of infamous and underreported true crime cases with her best friend Brit Prawat. From cold cases to missing persons and heroes in our community who seek justice, Crime Junkie is your destination for theories and stories you won’t hear anywhere else. Whether you're a seasoned true crime enthusiast or new to the genre, you'll find yourself on the edge of your seat awaiting a new episode every Monday. If you can never get enough true crime... Congratulations, you’ve found your people. Follow to join a community of Crime Junkies! Crime Junkie is presented by Audiochuck Media Company.

Advertise With Us
Music, radio and podcasts, all free. Listen online or download the iHeart App.

Connect

© 2026 iHeartMedia, Inc.

  • Help
  • Privacy Policy
  • Terms of Use
  • AdChoicesAd Choices