Why do SSRI drugs and the science behind them generate such fierce debate?

Psychiatrist Professor Joanna Moncrieff discusses her new book Chemical Imbalance: The Making and the Unmaking of the Serotonin Myth.

I first spoke to Joanna two years ago, just after she had published a review paper suggesting that there was no link between depression and an imbalance of serotonin in the brain.

And her book picks up what happened next. As her article gained more and more attention, she found herself in a political maelstrom facing vitriolic personal and professional criticism.

Because if the serotonin hypothesis was false, what could be the possible grounds for prescribing the popular antidepressants - the selective serotonin uptake inhibitors - better known as the SSRIs?  It’s been claimed in the past they can alter brain chemistry and correct imbalances, but how can they work if Joanna is right and no imbalance exists?

What followed illustrates the fierce political divide in psychiatry between those who remain sceptical of her claims and believe that the current medication for depression is a vital tool and those such as Joanna who are unconvinced by its value.

And we also discuss why much to her surprise, Joanna – although she has always been a socialist -  found far more sympathy for her research from right wing media sources rather than the left.

Chemical Imbalance: The Making and the Unmaking of the Serontonin Myth by Joanna Moncrieff is published by Flint Books.

The host of this award nominated podcast, Liz Tucker is an award winning medical journalist and former BBC producer and director.  You can follow Liz on Twitter at https://twitter.com/lizctucker and read her Substack newsletter about the podcast at https://liztucker.substack.com

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