Cardiac Output

Cardiac Output

Cardiac Output is a podcast on cardiothoracic anaesthesia and intensive care medicine. Dr Mike Charlesworth and Dr Calum Downes bring you tacit knowledge from a national transplant and ECMO centre — the reasoning that never makes it into the textbook.

Episodes

October 23, 2026 • 13 mins

After a straightforward valve operation, TAPSE is twelve millimetres — well under the transthoracic normal. But the fractional area change is 40 per cent, the 3D ejection fraction is 48 per cent, and the lactate is falling. Which number is lying?

This is part two of two on the right ventricle on transoesophageal echo, following the right ventricle chapter of the fourth edition of Practical Perioperative Transoesopha...

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In the 1940s, researchers burned away most of the right ventricular free wall in dogs, and the venous pressure barely moved. For decades, the right ventricle was treated as a passive conduit. Nobody who has watched one fail coming off bypass believes that now.

This is part one of two on the right ventricle on transoesophageal echo, built around the right ventricle chapter of the fourth edition of Practical Perioperative T...

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A patient comes for coronary bypass. Last month's echo called the mitral regurgitation severe. After induction, it looks moderate. The surgeon asks: "Do I need to touch the valve?"

This is part two of two on the mitral valve on transoesophageal echo, following the mitral valve chapter of the fourth edition of Practical Perioperative Transoesophageal Echocardiography. It's all about severity — and the rule that runs ...

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The cross-clamp is on, the atrium is open, and the surgeon looks up over the drapes: "Is it P2 or P3 — and is the anterior leaflet involved?" Everyone turns to the person with the TOE probe.

This is part one of two on the mitral valve on transoesophageal echo, built around the mitral valve chapter of the fourth edition of Practical Perioperative Transoesophageal Echocardiography. We start with why the mitral valve i...

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"Anaesthetist to the cath lab. Primary PCI, five minutes." Then the pause, while everyone waits to hear whether the patient is self-ventilating or intubated.

This episode is about anaesthesia for primary PCI — one of the few places where you're surrounded by people and still somehow on your own. We cover the range of patients the call can mean, from mid-arrest on a mechanical compression device to the agitated patie...

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In carcinoid syndrome, you must never give adrenaline. Most of us were taught that — but it comes from decades-old experiments in end-stage patients who had never been near octreotide. So does the rule still stand?

This episode is carcinoid heart disease, from the tumour to intensive care. We start with neuroendocrine tumours and carcinoid syndrome, why the syndrome usually needs liver metastases, and why serotonin ...

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October 13, 2026 • 15 mins

Sixty-five per cent of patients on standard-dose heparin on ECMO had a severe bleed. Eleven per cent had a severe clot. And the heparin is there to prevent the eleven.

This is a journal club on RATE, published in The Lancet in July 2026: the first adequately powered randomised trial of anticoagulation intensity on ECMO. Three hundred and thirty adults on veno-venous or veno-arterial ECMO across seven Dutch intensive ...

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October 11, 2026 • 18 mins

A thirty-four-year-old for a hernia repair. After induction the pressure falls to fifty systolic, and the trainee reaches for adrenaline. The echo shows a thick septum, a tiny cavity and the mitral leaflet slapping into the outflow tract — and the pressure gets much worse.

This episode is the cardiomyopathies: the main types, how they present, what they look like on echo, and why getting the label right changes what you ...

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Day one after mitral valve surgery. The monitor says the cardiac index is a healthy three point two. The lactate is six, the feet are cold and the urine has stopped. One of those numbers is lying — and it isn't the lactate.

This episode is cardiac output monitoring, for the exam and for the bedside: how each device works, the physiology underneath, when we actually use them, and where each one misleads you.

We start with...

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September 27, 2026 • 19 mins

Forty minutes into an aortic valve replacement, the cross-clamp is on and the heart is arrested. Then a little electrical activity starts creeping back on the ECG. What do you do? Tell the surgeon — out loud, straight away — because that heart is waking up while it's still ischaemic. The anaesthetist is part of myocardial protection, even though the solution runs through the perfusionist's pump.

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September 25, 2026 • 20 mins

Eight o'clock ward round, day two after a coronary artery bypass, and the monitor shows atrial fibrillation at a hundred and fifty. Calum's answer is amiodarone — and that is the single most common wrong answer on the unit. Not because amiodarone is wrong, but because of where it sits in the order.

This is atrial fibrillation on the cardiothoracic intensive care unit, top to bottom. And it matters be...

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September 21, 2026 • 15 mins

Last episode we put a probe on the chest. This one goes down the oesophagus — and it starts somewhere uncomfortable.

Inserting a transoesophageal probe is something we do to a patient that can cause them significant harm. Maybe once a year, sometimes more, a patient comes to harm because an anaesthetist put a probe down. We do a great many of these, so it is not unreasonable to think we sometimes cau...

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Three in the morning. A patient on the unit is hypotensive, the noradrenaline is going up, and somebody has already given a litre. What is the fastest way to actually know what's wrong?

Put a probe on them.

This is the first of two foundation episodes on echocardiography — the thing that turns a guess into a diagnosis, at the bedside, in about ninety seconds. Today it's transthoracic ech...

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Recorded minutes after the live launch at Annual Congress 2026, and published the same day the paper appears in Anaesthesia.

GLIMPSE — the GLP-1 receptor agonist Management in the Peri-operative Setting project — is a national, prospective, multicentre cohort study delivered through the UK resident research networks across all four nations, and it is the largest thing anyone has done on this qu...

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Before we touch a single image, we sort out the vocabulary — because almost everyone muddles these devices, and once you have muddled them you cannot reason about them. People say "VAD" and mean five different machines, sitting in different places, for different lengths of time.

So: three questions, and every device answers all three. Which ventricle? How long is it meant to stay in? Surgical or perc...

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We've spent a lot of this series on machines — balloon pumps, ECMO circuits, ventricular assist devices. This episode is about the tool that makes all three of them safe.

The argument is that in mechanical circulatory support, transoesophageal echo is not an investigation you order. It is part of the device. It confirms the indication, guides the cannulas in, optimises the support once it is running,...

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"Draw me a cardiopulmonary bypass circuit." Venous cannula, reservoir, pump, oxygenator, back to the aorta, cross-clamp, cardioplegia, vents, suckers. Good — that's a pass. The mark comes when you can say what each component does to the patient rather than what it does to the blood, and that is the difference between a trainee who has memorised a diagram and a senior who understands a machine.

This i...

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Two in the morning, day one after a long CABG. The patient has a balloon pump in, the augmented pressure has dropped, and the urine output has fallen away over the last three hours. The easiest thing in the world at that hour is to re-zero the transducer, decide the trace looks a bit better, and go back to what you were doing. By the end of this episode you'll know exactly why that's the wrong answer.

This...

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Something different this episode. No 3am emergency — instead, a pre-assessment clinic on a Tuesday afternoon, a woman booked for an aortic valve replacement in six weeks, and a haemoglobin of 118. Do you give her intravenous iron?

ITACS, published in The BMJ in August 2026, is the best answer we have ever had to that question. It is also a trial with a great deal to teach about how to read a paper pr...

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You will have noticed that consultants tend to give the protamine themselves, and if you're an ST3 who hasn't done much cardiac, nobody asks you to do it. Most people assume that's habit. It isn't.

This is the theatre half of the bleeding week — the drugs, the traps in the tests, and a salvage case at the far end of what's possible. Last episode was the unit.

Please note: the doses and d...

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