MedEvidence! Truth Behind the Data
Welcome to the MedEvidence! podcast, hosted by Dr. Michael Koren. MedEvidence, where we help you navigate the real truth behind medical research with both a clinical and research perspective. In this podcast, we will discuss with physicians with extensive experience in patient care and research. How do you know that something works? In medicine, we conduct clinical trials to see if things work! Now, let's get to the Truth Behind the Data. Contact us at www.MedEvidence.com
Episodes
Dr. Michael Koren sits down with a clinical trial participant named Walt to talk about lipoprotein(a), also called Lp(a). At a community health event, Walt discovered he had hight levels of Lp(a), which puts him at an increased risk of heart attack and stroke. Walt asks what Lp(a) is, how it causes damage, and how the investigational clinical trial medications work. The duo then move through how Walt has felt throug...
Dr. Michael Koren joins Kevin Geddings to discuss a new concept in cholesterol treatment: gene editing. Dr. Koren talks about a new study, just opening in the United States, that is the first of its class. This study explores gene editing to tackle familial hypercholesterolemia (high cholesterol caused by genetics) through a once-in-a-lifetime, single-shot treatment.
Rheumatologist Dr. Manish Jain joins Cardiologist Dr. Michael Koren to break down what gout is, why it can be one of the most painful forms of arthritis, and why it can affect far more than the big toe. Dr. Jain explains gout's metabolic underpinnings, the role uric acid plays in the disease, and how systemic complications can affect the kidneys and beyond. The doctoral duo then discusses what uric acid levels mean,...
Dr. Michael Koren and Dr. Ravi Pande present What You Should Know about Strokes, including how high cholesterol and blood pressure can increase your risk. In this episode, recorded in front of a live audience, the two doctors discuss the BE FAST warning signs of a stroke and the importance of getting to an emergency room as fast as possible. Then they talk about treatment options, including new medications and guide...
Dr. Michael Koren joins Kevin Geddings to discuss the Fatty's Liver's Domino Effect; the concept that a fatty liver can cascade into serious liver problems, including a need for a liver transplant. The duo also discusses the FibroScan, a non-invasive test to assess the level of fatty liver for at-risk individuals. They finish by talking about the importance of early diagnosis to stop the domino effect befo...
Dr. Robert Pearl joins Dr. Erich Schramm to discuss the burgeoning role AI will play in the American healthcare system and how doctors may be able to leverage the systems to spend more time with patients who need interventions and achieve better patient outcomes for all. They spend time comparing AI outcomes not to an ideal but to the current system, and discuss pilot programs that have shown better triage, interven...
Dr. Michael Koren joins Kevin Geddings to discuss an eventful weekend, focusing on the passing of singer, songwriter, and pianist Neil Sedaka. The doctor talks about how a teacher early in the musician's life changed his trajectory and that teachers in general undersand the importance of bringing students up to their potential. The doctor then relates this to clinical research, and how research specialists use ...
Dr. Gagandeep Singh joins Dr. Michael Koren to discuss his triangle approach, which combines the talents of a medical doctor, a nutritionist, and a trainer to tackle the medications, diets, and exercise changes needed to make a difference in metabolic diseases. Metabolic diseases include diabetes, hypertension, obesity, and polycystic ovary syndrome (PCOS). Dr. Singh, who practices in India, explains how this holist...
Dr. Michael Koren joins Kevin Geddings to contrast the fragmented NBC coverage of the Winter Olympics to the more comprehensive level of attention and care granted by clinical research staff. The doctor expresses woe at the lack of a national "moment" that should have been granted by back-to-back men's and women's hockey victories, caused by weak broadcast coverage. Dr. Koren gives a preview of c...
Endurance training coach Owen Shott joins cardiologist Michael Koren to discuss electrolytes. The two experts discuss the role of electrolytes in the body and in the commercial marketplace. They review what electrolytes are, the major electrolytes we need, why they may be depleted in some athletes, and how to restore electrolyte balance. They also review major supplement brands in an unbiased, non-sponsored manner, ...
Dr. Michael Koren joins Kevin Geddings to talk about the heart. They discuss the origins of Valentine's Day and how high cholesterol can affect the cardiovascular system, including the heart. Then Dr. Koren transitions into talking about new investigational cholesterol therapies being researched - including gene editing. The doctor explains what cholesterol is, how gene abnormalities can affect cholesterol leve...
Dr. Erich Schramm and Dr. Michael Koren lead a presentation on diabetes and obesity in front of a live audience. The doctors talk about the role willpower plays, how ultra-processed foods hijack our brain, and what a healthy diet looks like. They also discuss the myriad signaling molecules in the body that tell us we're hungry or full and when to digest all that food. The doctors also touch on the growing line ...
Dr. Michael Koren joins Kevin Geddings to talk about what the Super Bowl can teach us about medicine. The doctor discusses on how players get two weeks off to prepare (and heal) for the Super Bowl. He then relates this to a growing trend in investigational medicine where pharmaceutical companies are searching for longer-term medications for blood pressure and other conditions that only need to be taken once a month ...
Dr. H. Jackson Downey sits down with MedEvidence!™ to give the low-down on keeping your lipoprotein(a) numbers down. Lipoprotein little a, also called Lp(a), is a really, really, really, really, really bad cholesterol that is genetically determined, meaning exercise and diet don't help lower the numbers. Instead, Dr. Downey explains, clinical trials are looking into investigational medications for this bad type...
Dr. Michael Koren joins Kevin Geddings to relate his latest reading - the biography of the "father of the atomic bomb," J. Robert Oppenheimer - to medicine. He shares the sentiment that science is the practice of making the complex understandable, and explains that this is also the goal of medicine. The doctor explains the process of medicine as an effort to distill complicated circumstances into comprehen...
Dr. Mitchell Rothstein goes over the FibroScan, a liver scanning technology that produces fast and cheap measurements of liver fat content and fibrosis. Dr. Rothstein reviews what the FibroScan is, how it works, the process of getting a FibroScan, and what the results mean. The doctor explains when you should get a FibroScan, what to expect from the process, and the accuracy compared to invasive liver biopsies.
Dr. Michael Koren joins Kevin Geddings to offer the solace of taking control of your medical future in these uncertain times. The doctor reminds listeners that when news is stressful and chaotic, doing things that impact you and your life can help reduce anxiety. He suggests that taking advantage of free screening exams at clinical research sites may help people make sense of the otherwise mysterious and can help fi...
Dr. Erich Schramm joins Kevin Geddings to discuss a new study which aims to lower the incidence of childhood obesity. Somewhere around 1 in 3 children are overweight or obese, and this condition greatly increases the risks of serious health consequences later in life, including diabetes, high blood pressure, high cholestrol, and metabolic disorders. Dr. Schramm talks about what is being done today in the world of cl...
Dr. A. Mark Fendrick joins Dr. Michael Koren to discuss his life and legacy promoting value-based insurance design (VBID). VBID is the idea is that procedures which are neccecary should cost patients less than thsoe that are optional, and is seen in the US with many insurance plans offering 100% coverage of preventative services. Dr. Fendrick recounts his career and how he managed to get VBID language in healthcare ...
Dr. Michael Koren joins Kevin Geddings to explain what "Phase 1" means in the context of clinical research. The doctor talks about how phase 1 is the first time a new investigational treatment is used in a person, but that there is an enormous amount of work that happens before a medication gets to that point. He also discusses the other phases of research, concerns about safety, and why clinical research ...
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