Episode 238 - How Diet Fixes More Than You Could Possibly Imagine And Vice-versa

Gut Immune Body Brain Axis.
Dr Gundry:
Leaky Gut, gut microbiome and diet
Renowned Cardiovascular Surgeon who realised that all he was doing was treating the
symptoms so he studied the underlying causes.
The lining of the gut is one cell thick
As bacteria break down the gut that is when ageing starts
Ibuprofen or roundup disastrous the bacteria population
Skin is a mirror of the lining of the gut
Joints do not naturally wear out.
Animal model C Elegans as bacteria begin to break down the wall of the gut that is when
ageing starts
105 year old people have a diverse set of bugs identical to a healthy 30 year old. It is not
attacking the wall of the gut.
Ecermansia musinophilia. Lives in the mucous layer whose job is to trap lectins plant
proteins looking for sugar molecules and to protect the wall of the gut from harmful bacteria.
Ecermansia musinophilia eats mucus which in turn makes more mucus.
Metformin works by increasing mucous and this change in bacteria makes some people
have mild diarrhoea as the bacteria change.
If we damage this lining eg ibuprofen or food with roundup destroys the bacteria population
and gut lining.
Glyocosade an antibacterial damages Ecermansia Musinophilia even though it does not
directly affect human cells.
Antibiotics in food or direct prescription eg ladies who take low dose for UTI have a higher
incidence of heart disease.
Heart disease is an autoimmune disease starting in the gut.
Cholesterol is an innocent bystander which gets sucked into the inflamed wall of a blood
vessel.
Infants with heart transplants have coronary artery disease with pathology identical with
typical coronary artery disease.
Lectins which are a foreign protein which can stick to sugar molecules on the surface of
blood vessels are the cause of atherosclerosis and removing lectins reduces those markers.
Lectins are one of the plant defence systems. Sticky proteins that look for specific sugar
molecules to stick to which insights an inflammtory response.
Joints do not normally wear out. Usually you can find bacterial particles in the joint fluid of
arthritis
Because
Lectins broke down the wall of the gut. 65% of the immune system is behind the wall of the
gut because the gut is where the outside word gets through. A reason why we store fat in
the gut is to provide energy to the immune system. Similarly fat on the outside of
atherosclerotcic blood vessles correlates with the severity of inflammation.
Fat is not the cause . It is there because of the inflammation and the inflammation is there
due to the leaky gut.
The immune system responds to antigens on bacteria of viruses. Lectins have antigens with
cross reactivity with other proteins in the body. Eg thyroid.
Nightshade vegetables or peanuts
Lectins disrupt the microbiome and break up the lining of the gut allowing entry by lectins
and by bacteria or bacterial particles.
Hence if you inject a bacterial lipopolysaccharide into a person you can induce septic shock.
Alzheimers Parkinsons is neuroinflammation.
Most amyloid is produced by bacteria in the gut. Therefore 40 billion dollars invested in
antiamyloid drugs has been a waste because amyloid is produced by the amyloid producing
bacteria inthe gut fet by western diet. Then the amyloid has to get through the wall of the gut.
Once they get through the gut wall and goto the brain it will produce more amyloid.
Cholesterol and amyloid coexist in dementia in those with the apoE gene.
The apo E gene codes for a carrier molecule because it is less efficient at transporting
cholesterol. It cannot get out of the cell after it has been attracted by inflammation.
Faecal microbial transplant:
1970s broad spectrum antibiotics came out which made it much quicker to treat infections
but it also wiped out the gut bacteria. Normally 10000 species of bacteria.
Pseudomembranous colitis was caused by Clostridium Difficile over growing. Initial study
done from the faeces of medical students.
Faecal enemas treated the pseudomembranous colitis.
Meat with animals treated by antibiotics can also cause problems.
60% of faeces is bacteria
Oral microbiome and cloud of bacteria around us –Holobiome . This defines our personal
space.
Kissing is a human and ape characteristic. Exchanging oral microbiome. Bacteria decide
whether the other person's bacteria are compatible with them.
Women have a gut feeling because they are more capable of listening to their microbiome.
We inherit our microbiome from our mother. All of the mitochondria are involved with bacteria
inherited from our mother. Bacteria communicate to their ‘sisters ’ie the body’s mitochondria.
Autism: kids have a differ