Join Dr. Sanjeev Goel in an interview with Dr. Raghav Sehgal, a PhD student at Yale and expert in epigenetic clocks. Discover how Dr. Sehgal's research sheds light on aging, from predicting chronological age to understanding the pace of aging and mortality risk. Learn about the concept of "systems age" and how different organs age at varying rates, impacting disease prevalence. Explore the potential for personalized treatments based on these findings. Dr. Sehgal also discusses the impact of lifestyle factors like diet and exercise on reversing epigenetic aging, offering practical insights for a healthier, more youthful life.
TIMESTAMPS:
00:00 - Introduction
01:05 - Background and Entry into Epigenetic Clocks
09:03 - History of Epigenetic Clocks
17:00 - Systems Age: Measuring Aging in 11 Organs
19:02 - Importance and Significance of Systems Age
20:04 Aging Clusters
22:26 Cardiovascular Disease Clusters
24:56 Impact of Alcohol on Aging
27:52 Reversibility of Epigenetic Clocks
30:11 Impact of Diet on Aging
35:43 Personalized Recommendations
38:51 Exercise and Longevity
39:31 Availability of Systems Clock
40:05 Future Projects
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Link to Study https://jamanetwork.com/journals/jama...
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