The Carolina Breast Cancer Study - Ep1

Overview: The Carolina Breast Cancer Study

African American breast cancer patients are less likely to be diagnosed with hormone receptor-positive, HER2-negative breast cancer and they have higher subtype-specific mortality. Racial differences in molecular subtype within clinically defined subgroups were not well understood. The Carolina Breast Cancer Study was designed to help address knowledge gaps in the variation in breast cancer subtypes in AA women vs White women and how this potentially impacted breast cancer mortality. Additional publications also discussed the impact of Black women having higher hormone receptor positive (HR+) breast cancer mortality than White women. Early recurrence rates differ by race, but little was known about genomic predictors of early recurrence among HR+ women. This podcast will review the background of why the CBCS was started, the study design, funding of the study, and the translational science that was developed as a result. Finally, will discuss how these finding can impact public health policy and the care of African America women with breast cancer with the goal to help bridge this gap in breast cancer related mortality.

Target Audience:

Professionals involved in Breast Cancer Care including but not limited to: Students (residents, fellows, post docs, graduate, nursing, advanced practitioners, allied health) Health care providers (physician, nurses, advanced care providers) Advocates Basic and Translational scientist Pharmaceutical industry

Learning Objectives for the Episode

1. Review molecular difference in breast cancer subtype incidence by race
2. Gain awareness of disparity in clinical outcomes between AA women and White women with breast cancer
3. Become familiar with the PAM50 breast cancer profiling and how it is utilized but clinically and in translational research.
4. Increase knowledge in clinical trial designs that inform population based health care research

Faculty Kate Lathrop, MD

 

Melissa Troester, PhD

 

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