July 23, 2022 • 43 mins
Coaching: Anxiety Disorder:
We all have anxiety, not only is it normal it is essential for survival, in fact as a caveman the
more anxiety you had the more likely you were to escape predators and achieve survival
needs. The irony is that in todays society it these people that suffer the most as just like the
rest of us they are hard wired to continue escaping illusionary predators and acquire
illusionary survival needs that marketing and social media imprison us with.
We discussed stress last week which is mostly a normal response for an individual to a
situation where they do not feel in control
However if severity of anxiety or duration exceeds what is reasonable then it may become a
clinical disorder.
Anxiety Disorder:
33% life time prevalence of anxiety disorder often co morbid with depression or other
anxiety disorders, and 4% life time prevalence of GAD higher and more impairing in high
income countries. Females twice as likely as males.
Generalised Anxiety Disorder: DSM V 300.02
Generalised Anxiety Disorder: 8 studies of biological interventions:
Current Psychiatry July 2022 Saeed Majarwitz
Generalised Anxiety Disorder usually starts in early adulthood and persists throughout life.
Anxiety about a variety of events is excessive and unreasonable and causes distress and
impairs functioning.
There is a big variability in the effectiveness of physical intervention for Generalised Anxiety
Disorder.
SSRI, SNRI, agomelatine (melatonin 1 and 2 R agonist and 5HT 2c R antagonist –
antagonism increases noradrenaline and dopamine)- as effective as SSRI maybe with fewer
side effects eg nausea and sexual side effects.
Less used: Buspirone - 5HT 1a R agonist.
Acute anxiety: Benzodiazepine.
rTMS (FDA approval for Clinical depression 2008) right parietal cortex or right dorsolateral
prefrontal cortex with reduced relapse after completion of treatment.
CBT alone and improves response to medication.
Plus:
Diet exercise reduce alcohol and cigarettes, structure , self awareness , sleep with positive
studies for magnesium, chamomile extract and antioxidants.
Cross-sectional Comparison of the Epidemiology of DSM-5 Generalized Anxiety Disorder
Across the Globe
Ayelet Meron Ruscio, PhD1
; Lauren S. Hallion, PhD2
; Carmen C. W. Lim, MSc3
; et al
Dialogues Clin Neurosci. 2015 Sep; 17(3): 327–335.
Epidemiology of anxiety disorders in the 21st century
Borwin Bandelow, MD, PhD*
Ann Behav Med. Author manuscript; available in PMC 2016 Aug 1.
Generalised Anxiety Disorder: 8 studies of biological interventions:
Current Psychiatry July 2022 Saeed Majarwitz
Published in final edited form as:
Ann Behav Med. 2015 Aug; 49(4): 542–556
Exercise as Treatment for Anxiety: Systematic Review and Analysis
We all have anxiety, not only is it normal it is essential for survival, in fact as a caveman the
more anxiety you had the more likely you were to escape predators and achieve survival
needs. The irony is that in todays society it these people that suffer the most as just like the
rest of us they are hard wired to continue escaping illusionary predators and acquire
illusionary survival needs that marketing and social media imprison us with.
We discussed stress last week which is mostly a normal response for an individual to a
situation where they do not feel in control
However if severity of anxiety or duration exceeds what is reasonable then it may become a
clinical disorder.
Anxiety Disorder:
33% life time prevalence of anxiety disorder often co morbid with depression or other
anxiety disorders, and 4% life time prevalence of GAD higher and more impairing in high
income countries. Females twice as likely as males.
Generalised Anxiety Disorder: DSM V 300.02
Generalised Anxiety Disorder: 8 studies of biological interventions:
Current Psychiatry July 2022 Saeed Majarwitz
Generalised Anxiety Disorder usually starts in early adulthood and persists throughout life.
Anxiety about a variety of events is excessive and unreasonable and causes distress and
impairs functioning.
There is a big variability in the effectiveness of physical intervention for Generalised Anxiety
Disorder.
SSRI, SNRI, agomelatine (melatonin 1 and 2 R agonist and 5HT 2c R antagonist –
antagonism increases noradrenaline and dopamine)- as effective as SSRI maybe with fewer
side effects eg nausea and sexual side effects.
Less used: Buspirone - 5HT 1a R agonist.
Acute anxiety: Benzodiazepine.
rTMS (FDA approval for Clinical depression 2008) right parietal cortex or right dorsolateral
prefrontal cortex with reduced relapse after completion of treatment.
CBT alone and improves response to medication.
Plus:
Diet exercise reduce alcohol and cigarettes, structure , self awareness , sleep with positive
studies for magnesium, chamomile extract and antioxidants.
Cross-sectional Comparison of the Epidemiology of DSM-5 Generalized Anxiety Disorder
Across the Globe
Ayelet Meron Ruscio, PhD1
; Lauren S. Hallion, PhD2
; Carmen C. W. Lim, MSc3
; et al
Dialogues Clin Neurosci. 2015 Sep; 17(3): 327–335.
Epidemiology of anxiety disorders in the 21st century
Borwin Bandelow, MD, PhD*
Ann Behav Med. Author manuscript; available in PMC 2016 Aug 1.
Generalised Anxiety Disorder: 8 studies of biological interventions:
Current Psychiatry July 2022 Saeed Majarwitz
Published in final edited form as:
Ann Behav Med. 2015 Aug; 49(4): 542–556
Exercise as Treatment for Anxiety: Systematic Review and Analysis
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